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• W2325885128 abstract "The Aurora kinases are essential for cell mitosis, and the dysregulation of Aurora A and B have been linked to the etiology of human cancers. Investigational agents MLN8054 (8) and alisertib (MLN8237, 10) have been identified as high affinity, selective, orally bioavailable inhibitors of Aurora A that have advanced into human clinical trials. Alisertib (10) is currently being evaluated in multiple Phase II and III clinical trials in hematological malignancies and solid tumors." @default.
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• W2325885128 date "2015-05-05" @default.
• W2325885128 modified "2023-10-13" @default.
• W2325885128 title "MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors" @default.
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• W2325885128 doi "https://doi.org/10.1021/ml500409n" @default.
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