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- W2325895488 abstract "Background Osteoarthritis (OA) is the most common adult joint disease characterized by cartilage destruction, subchondral bone remodelling and mild synovial inflammation. Pathogenesis of OA involves overload, ageing, genetic factors and chondrocyte dysregulation. Galectin 3 (Gal3) expression is increased in OA cartilage and synovial fluid. Gal3 is involved in multiple cellular functions including proliferation, differentiation and cell death. During embryogenesis, the growth plate of Gal3 mutant mice has a reduction of hypertrophic zone and many lacunae due to a loss of chondrocytes. These results suggest a role of Gal3 in chondrocyte dedifferentiation. Objectives To determine the role of Gal3 in osteoarthritis and to assess its functions in chondrocyte biology. Methods In vivo , murine OA was induced in Wild type (WT) 129 and Gal3 mutant mice by partial medial meniscectomy (MNX) of the right knee. A sham operation was performed on the left knee. Animals were sacrificed 4 weeks after surgery. Cartilages lesions were assessed according to OARSI recommendations. Chondrocyte apoptosis was assessed by TUNEL labelling and chondrocyte catabolism by immunostaining for aggrecanases and metalloproteases. Subchondral bone modifications were evaluated by microCT. In vitro , primary murine chondrocytes, isolated from new born WT and Gal3 mutant mice, were cultured and stimulated by inflammatory cytokines (IL-1β and TNF-α). Anabolism, catabolic and differentiation responses were assessed by RT-qPCR Results In vivo , MNX induced in Gal3 mutant mice more severe OA cartilage lesions compared to WT as assessed by OARSI scoring (4.4±1.0 vs 1.3±0.8, p Conclusions Gal3 deletion exacerbated murine OA lesions induced by mechanical stress. OA lesions were associated with increased chondrocyte catabolism, differentiation and death. These results suggested Gal3 had a protective role in OA and chondrocyte homeostasis. Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.4750" @default.
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- W2325895488 date "2014-06-01" @default.
- W2325895488 modified "2023-10-18" @default.
- W2325895488 title "SAT0569 Galectin 3 Exerts A Protective Role in A Murine Model of Osteoarthritis" @default.
- W2325895488 doi "https://doi.org/10.1136/annrheumdis-2014-eular.4750" @default.
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