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• W2325968884 abstract "Hypoxic cellular response is crucial for normal development as well as in pathological conditions in order to tolerate low oxygen. The response is mediated by Hypoxia Inducible Factors (HIFs), where the α-subunit of HIF is stabilised and able to function only in low oxygen. Prolyl hydroxylases (PHDs) are oxygen dependent dioxygenase enzymes that hydroxylate HIF-α leading to HIF degradation. Thus PHDs function as an oxygen sensor for the function of HIFs. Here we describe the mRNA expression pattern of PHDs in chick embryos. Up to embryonic day 2, PHDs are weak without specific localisation, whereas from day 3 localised expression was observed in the eye, branchial arches and dermomyotome. Later in the limb development PHDs were expressed in the perichondral mesenchyme, excluded from the developing limb cartilages." @default.
• W2325968884 created "2016-06-24" @default.
• W2325968884 creator A5057040195 @default.
• W2325968884 creator A5081294430 @default.
• W2325968884 date "2016-07-01" @default.
• W2325968884 modified "2023-09-27" @default.
• W2325968884 title "Expression of prolyl hydroxylases 2 and 3 in chick embryos" @default.
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• W2325968884 doi "https://doi.org/10.1016/j.gep.2016.04.001" @default.
• W2325968884 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27063263" @default.
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