FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2325983460> ?p ?o ?g. }

• W2325983460 endingPage "264" @default.
• W2325983460 startingPage "258" @default.
• W2325983460 abstract "Purpose of review RANK ligand (RANKL) plays a central role in the cancer-induced bone destruction that results from bone metastasis. The RANKL inhibitor denosumab was recently approved for the prevention of skeletal-related events (SREs) in patients with bone metastases from solid tumors. This review summarizes recent findings of the effects of RANKL inhibition and denosumab in the cancer setting. Recent findings Preclinical data show that RANKL inhibition in combination with antitumor therapies has additive effects on preventing skeletal tumor progression. Preclinical breast cancer models also suggest RANKL may be involved in primary tumorigenesis and establishment of metastases in bone and other tissues. Pivotal clinical trial data with denosumab in advanced cancer patients across tumor types showed it was superior (breast and prostate) or noninferior trending toward superior (solid tumors/multiple myeloma) to zoledronic acid, in reducing the risk of developing an SRE and demonstrated a favorable safety profile. Denosumab has also demonstrated efficacy in the treatment of giant cell tumor of bone. Summary Denosumab offers an important new treatment option for patients with solid tumors and bone metastases. The efficacy of RANKL inhibition with denosumab in other disease states in the cancer setting continues to be evaluated." @default.
• W2325983460 created "2016-06-24" @default.
• W2325983460 creator A5018551530 @default.
• W2325983460 creator A5047198395 @default.
• W2325983460 date "2011-09-01" @default.
• W2325983460 modified "2023-10-10" @default.
• W2325983460 title "Denosumab" @default.
• W2325983460 cites W1855324168 @default.
• W2325983460 cites W190773286 @default.
• W2325983460 cites W1964066819 @default.
• W2325983460 cites W1966110021 @default.
• W2325983460 cites W1967615426 @default.
• W2325983460 cites W1970222099 @default.
• W2325983460 cites W1971949613 @default.
• W2325983460 cites W1974140746 @default.
• W2325983460 cites W1974425256 @default.
• W2325983460 cites W1989526399 @default.
• W2325983460 cites W2005558806 @default.
• W2325983460 cites W2023398724 @default.
• W2325983460 cites W2027213496 @default.
• W2325983460 cites W2031211482 @default.
• W2325983460 cites W2034033154 @default.
• W2325983460 cites W2048299560 @default.
• W2325983460 cites W2061144117 @default.
• W2325983460 cites W2066000727 @default.
• W2325983460 cites W2081417661 @default.
• W2325983460 cites W2086491566 @default.
• W2325983460 cites W2089925954 @default.
• W2325983460 cites W2094246598 @default.
• W2325983460 cites W2103904089 @default.
• W2325983460 cites W2108248718 @default.
• W2325983460 cites W2112523271 @default.
• W2325983460 cites W2113701976 @default.
• W2325983460 cites W2114935509 @default.
• W2325983460 cites W2133551420 @default.
• W2325983460 cites W2139860898 @default.
• W2325983460 cites W2145928668 @default.
• W2325983460 cites W2149775776 @default.
• W2325983460 cites W2157193896 @default.
• W2325983460 cites W2159152276 @default.
• W2325983460 cites W2165011173 @default.
• W2325983460 cites W2166303017 @default.
• W2325983460 cites W2167030358 @default.
• W2325983460 cites W2167886526 @default.
• W2325983460 cites W2170527535 @default.
• W2325983460 cites W282464114 @default.
• W2325983460 doi "https://doi.org/10.1097/spc.0b013e328349731c" @default.
• W2325983460 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21826000" @default.
• W2325983460 hasPublicationYear "2011" @default.
• W2325983460 type Work @default.
• W2325983460 sameAs 2325983460 @default.
• W2325983460 citedByCount "24" @default.
• W2325983460 countsByYear W23259834602012 @default.
• W2325983460 countsByYear W23259834602013 @default.
• W2325983460 countsByYear W23259834602014 @default.
• W2325983460 countsByYear W23259834602016 @default.
• W2325983460 countsByYear W23259834602018 @default.
• W2325983460 countsByYear W23259834602019 @default.
• W2325983460 countsByYear W23259834602020 @default.
• W2325983460 countsByYear W23259834602021 @default.
• W2325983460 countsByYear W23259834602022 @default.
• W2325983460 crossrefType "journal-article" @default.
• W2325983460 hasAuthorship W2325983460A5018551530 @default.
• W2325983460 hasAuthorship W2325983460A5047198395 @default.
• W2325983460 hasConcept C121608353 @default.
• W2325983460 hasConcept C126322002 @default.
• W2325983460 hasConcept C143998085 @default.
• W2325983460 hasConcept C170493617 @default.
• W2325983460 hasConcept C2776286101 @default.
• W2325983460 hasConcept C2776326535 @default.
• W2325983460 hasConcept C2776364478 @default.
• W2325983460 hasConcept C2776541429 @default.
• W2325983460 hasConcept C2777783956 @default.
• W2325983460 hasConcept C2779013556 @default.
• W2325983460 hasConcept C2779428903 @default.
• W2325983460 hasConcept C2780192828 @default.
• W2325983460 hasConcept C502942594 @default.
• W2325983460 hasConcept C530470458 @default.
• W2325983460 hasConcept C71924100 @default.
• W2325983460 hasConcept C88045685 @default.
• W2325983460 hasConceptScore W2325983460C121608353 @default.
• W2325983460 hasConceptScore W2325983460C126322002 @default.
• W2325983460 hasConceptScore W2325983460C143998085 @default.
• W2325983460 hasConceptScore W2325983460C170493617 @default.
• W2325983460 hasConceptScore W2325983460C2776286101 @default.
• W2325983460 hasConceptScore W2325983460C2776326535 @default.
• W2325983460 hasConceptScore W2325983460C2776364478 @default.
• W2325983460 hasConceptScore W2325983460C2776541429 @default.
• W2325983460 hasConceptScore W2325983460C2777783956 @default.
• W2325983460 hasConceptScore W2325983460C2779013556 @default.
• W2325983460 hasConceptScore W2325983460C2779428903 @default.
• W2325983460 hasConceptScore W2325983460C2780192828 @default.
• W2325983460 hasConceptScore W2325983460C502942594 @default.
• W2325983460 hasConceptScore W2325983460C530470458 @default.
• W2325983460 hasConceptScore W2325983460C71924100 @default.
• W2325983460 hasConceptScore W2325983460C88045685 @default.
• W2325983460 hasIssue "3" @default.
• W2325983460 hasLocation W23259834601 @default.

• next