FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2326007239> ?p ?o ?g. }

• W2326007239 endingPage "250" @default.
• W2326007239 startingPage "239" @default.
• W2326007239 abstract "The treatment of patients with malignant brain tumors, in particular glioblastoma multiforme (GBM) is very challenging because of their diffuse infiltrative nature and the cytological heterogeneity. The median survival of patients with newly diagnosed GBM is only 12-15 months, and only 8-12% of them survive for two years. Novel approaches for brain tumor therapy are needed. Recently, targeted therapies have emerged as promising modality for cancer targeting. We have discovered that high affinity plasma membrane receptor for interleukin-13 (IL-13), an immune regulatory cytokine, is over-expressed in 60-80% of malignant brain tumors. To target these IL-13R, we generated a chimeric fusion protein, composed of human IL-13 and mutated Pseudomonas exotoxin (PE), termed IL-13 cytotoxin (IL13-PE), and tested its cytotoxicity to IL-13R-expressing GBM cells. IL-13 cytotoxin was highly potent and selective in killing IL-13R-expressing GBM cells. In contrast, normal cells including brain, immune, and endothelial cells were generally not affected by this cytotoxin due to no or low expression of IL-13R. In vivo pre-clinical studies for safety and toxicity were also performed in mice, rats, and monkeys, and IL-13 cytotoxin was found to be well tolerated by both systemic and intracerebral administrations. IL-13 cytotoxin was found to mediate remarkable efficacy in animal models of human brain tumors. Encouraged by these pre-clinical studies, four Phase 1/2 clinical trials in adult patients with recurrent malignant glioma have been completed. These clinical trials involved convection-enhanced delivery (CED) of IL-13 cytotoxin either intratumoral or intraparenchymal after resection of tumor. CED is a novel loco-regional drug delivery method for intracranial tumors that relies on a continuous pressure gradient to distribute drug into interstitial space. This route of IL-13 cytotoxin administration appears to be very well tolerated and have a good risk-benefit profile. Most recently, a randomized controlled Phase 3 clinical trial (PRECISE) with intraparenchymal IL-13 cytotoxin administration was completed and subjects are being monitored for safety and survival." @default.
• W2326007239 created "2016-06-24" @default.
• W2326007239 creator A5000733513 @default.
• W2326007239 creator A5004784274 @default.
• W2326007239 creator A5042398172 @default.
• W2326007239 creator A5067972591 @default.
• W2326007239 creator A5081807758 @default.
• W2326007239 date "2006-06-01" @default.
• W2326007239 modified "2023-09-23" @default.
• W2326007239 title "Convection-enhanced Delivery of Interleukin-13 Receptor-directed Cytotoxin for Malignant Glioma Therapy*" @default.
• W2326007239 cites W116096765 @default.
• W2326007239 cites W147266749 @default.
• W2326007239 cites W1521872585 @default.
• W2326007239 cites W1534592663 @default.
• W2326007239 cites W1538328956 @default.
• W2326007239 cites W1851144564 @default.
• W2326007239 cites W187893052 @default.
• W2326007239 cites W189779977 @default.
• W2326007239 cites W1958440406 @default.
• W2326007239 cites W1971334971 @default.
• W2326007239 cites W1972497890 @default.
• W2326007239 cites W1972624864 @default.
• W2326007239 cites W1982222256 @default.
• W2326007239 cites W1983805959 @default.
• W2326007239 cites W1983852551 @default.
• W2326007239 cites W1987408132 @default.
• W2326007239 cites W1990408233 @default.
• W2326007239 cites W1990761369 @default.
• W2326007239 cites W2002820450 @default.
• W2326007239 cites W2004376103 @default.
• W2326007239 cites W2006104156 @default.
• W2326007239 cites W2007163754 @default.
• W2326007239 cites W2009291555 @default.
• W2326007239 cites W2022047142 @default.
• W2326007239 cites W2023668782 @default.
• W2326007239 cites W2025435159 @default.
• W2326007239 cites W2026179616 @default.
• W2326007239 cites W2037342239 @default.
• W2326007239 cites W2039816707 @default.
• W2326007239 cites W2040108818 @default.
• W2326007239 cites W2041325626 @default.
• W2326007239 cites W2043784957 @default.
• W2326007239 cites W2043947842 @default.
• W2326007239 cites W2044013857 @default.
• W2326007239 cites W2044094798 @default.
• W2326007239 cites W2044673785 @default.
• W2326007239 cites W2058120223 @default.
• W2326007239 cites W2058255233 @default.
• W2326007239 cites W2066475464 @default.
• W2326007239 cites W2077709559 @default.
• W2326007239 cites W2082515801 @default.
• W2326007239 cites W2082833890 @default.
• W2326007239 cites W2089301184 @default.
• W2326007239 cites W2094163515 @default.
• W2326007239 cites W2096287682 @default.
• W2326007239 cites W2100683309 @default.
• W2326007239 cites W2103307075 @default.
• W2326007239 cites W2104684508 @default.
• W2326007239 cites W2109839172 @default.
• W2326007239 cites W2119977183 @default.
• W2326007239 cites W2124566107 @default.
• W2326007239 cites W2129369947 @default.
• W2326007239 cites W2132403618 @default.
• W2326007239 cites W213480149 @default.
• W2326007239 cites W2135062838 @default.
• W2326007239 cites W2141311899 @default.
• W2326007239 cites W2147019056 @default.
• W2326007239 cites W2155006652 @default.
• W2326007239 cites W2168265423 @default.
• W2326007239 cites W2168938667 @default.
• W2326007239 cites W2169103384 @default.
• W2326007239 cites W2173500887 @default.
• W2326007239 cites W2176801482 @default.
• W2326007239 cites W2177651721 @default.
• W2326007239 cites W2230578331 @default.
• W2326007239 cites W2239648790 @default.
• W2326007239 cites W2244251299 @default.
• W2326007239 cites W2370823328 @default.
• W2326007239 cites W4236953080 @default.
• W2326007239 cites W4255289481 @default.
• W2326007239 cites W4313333805 @default.
• W2326007239 cites W5786864 @default.
• W2326007239 cites W7092856 @default.
• W2326007239 doi "https://doi.org/10.1177/153303460600500307" @default.
• W2326007239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16700620" @default.
• W2326007239 hasPublicationYear "2006" @default.
• W2326007239 type Work @default.
• W2326007239 sameAs 2326007239 @default.
• W2326007239 citedByCount "60" @default.
• W2326007239 countsByYear W23260072392012 @default.
• W2326007239 countsByYear W23260072392013 @default.
• W2326007239 countsByYear W23260072392014 @default.
• W2326007239 countsByYear W23260072392015 @default.
• W2326007239 countsByYear W23260072392016 @default.
• W2326007239 countsByYear W23260072392017 @default.
• W2326007239 countsByYear W23260072392018 @default.
• W2326007239 countsByYear W23260072392019 @default.
• W2326007239 countsByYear W23260072392020 @default.

• next