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• W2326014721 abstract "Event Abstract Back to Event Exploiting NKG2D and lymphoid stress surveillance response in seronegative spondyloarthritis Elisa Binda1*, Antonio Manzo1, Barbara Vitolo2, Serena Bugatti1, 2 and Carlomaurizio Montecucco1, 2 1 University of Pavia, Italy 2 IRCCS University Hospital San Matteo Foundation, Italy A number of biomarkers are currently being investigated in patients with seronegative spondyloarthitis (SpA) since they may be used to predict exacerbation and monitor the clinical response to an intervention. Natural killer group 2, member D (NKG2D) is an activating receptor present on the surface of natural killer (NK), CD8 T cells, γδ T cells and under certain conditions CD4 T cells. NKG2D receptor binds to a family of ligands that are distant relatives of major histocompatibility complex class I molecules. Environmental stress such as genotoxic/oxidative stress, heat shock and viral infections stimulate NKG2D ligands expression. Recent studies have demonstrated that NKG2D ligands are induced on proliferating rheumatoid arthritis (RA) synoviocytes and may thus contribute to progression of rheumatic disease. Here we investigate the expression of NKG2D ligands in synovial tissue from SpA patients and we compare it with samples from RA patients and healthy controls. We monitor NKG2D regulation also in in-vitro cultured SpA and RA synoviocytes in response to physiological stimuli such as oxidative stress, heat-shock and mechanic stretch. Downregulation of NKG2D receptor on peripheral blood mononuclear cells (PBMC) represents a physiological regulatory mechanism of NK and gd T cells in response to activation and it is mediated by the production of pro-inflammatory proteins. Hence the production of key cytokines by circulating NKG2D+ cells may indicate the impaired response of the immune system to stress in rheumatic disease. We believe that understanding the contribution of NKG2D pathway in rheumatic pathologies may provide rational for emerging targeted therapies Keywords: NKG2D, NKG2D ligands, seronegative spondyloarthritis, lymphoid stress surveillance, Autoimmunity Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Immune-mediated disease pathogenesis Citation: Binda E, Manzo A, Vitolo B, Bugatti S and Montecucco C (2013). Exploiting NKG2D and lymphoid stress surveillance response in seronegative spondyloarthritis. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00712 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 13 Jun 2013; Published Online: 22 Aug 2013. * Correspondence: Dr. Elisa Binda, University of Pavia, Pavia, Italy, elibinda@hotmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Elisa Binda Antonio Manzo Barbara Vitolo Serena Bugatti Carlomaurizio Montecucco Google Elisa Binda Antonio Manzo Barbara Vitolo Serena Bugatti Carlomaurizio Montecucco Google Scholar Elisa Binda Antonio Manzo Barbara Vitolo Serena Bugatti Carlomaurizio Montecucco PubMed Elisa Binda Antonio Manzo Barbara Vitolo Serena Bugatti Carlomaurizio Montecucco Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2326014721 title "Exploiting NKG2D and lymphoid stress surveillance response in seronegative spondyloarthritis" @default.
• W2326014721 doi "https://doi.org/10.3389/conf.fimmu.2013.02.00712" @default.
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