Matches in SemOpenAlex for { <https://semopenalex.org/work/W2326059418> ?p ?o ?g. }
- W2326059418 endingPage "174" @default.
- W2326059418 startingPage "159" @default.
- W2326059418 abstract "Next-generation sequencing (NGS) technologies allow for the generation of whole exome or whole genome sequencing data, which can be used to identify novel genetic alterations associated with defined phenotypes or to expedite discovery of functional variants for improved patient care. Because this robust technology has the ability to identify all mutations within a genome, incidental findings (IF)- genetic alterations associated with conditions or diseases unrelated to the patient's present condition for which current tests are being performed- may have important clinical ramifications. The current debate among genetic scientists and clinicians focuses on the following questions: 1) should any IF be disclosed to patients, and 2) which IF should be disclosed - actionable mutations, variants of unknown significance, or all IF? Policies for disclosure of IF are being developed for when and how to convey these findings and whether adults, minors, or individuals unable to provide consent have the right to refuse receipt of IF. In this review, we detail current NGS technology platforms, discuss pressing issues regarding disclosure of IF, and how IF are currently being handled in prenatal, pediatric, and adult patients." @default.
- W2326059418 created "2016-06-24" @default.
- W2326059418 creator A5014595154 @default.
- W2326059418 creator A5024995944 @default.
- W2326059418 creator A5026323263 @default.
- W2326059418 creator A5034184965 @default.
- W2326059418 creator A5037701273 @default.
- W2326059418 creator A5059172090 @default.
- W2326059418 date "2015-04-09" @default.
- W2326059418 modified "2023-09-27" @default.
- W2326059418 title "Management of Incidental Findings in the Era of Next-generation Sequencing" @default.
- W2326059418 cites W1557996371 @default.
- W2326059418 cites W1599485646 @default.
- W2326059418 cites W1608171675 @default.
- W2326059418 cites W1836811906 @default.
- W2326059418 cites W1851713763 @default.
- W2326059418 cites W1947269196 @default.
- W2326059418 cites W1967295226 @default.
- W2326059418 cites W1972695780 @default.
- W2326059418 cites W1972922858 @default.
- W2326059418 cites W1973950074 @default.
- W2326059418 cites W1974035086 @default.
- W2326059418 cites W1974407984 @default.
- W2326059418 cites W1980171391 @default.
- W2326059418 cites W1983973208 @default.
- W2326059418 cites W1989098979 @default.
- W2326059418 cites W1993980022 @default.
- W2326059418 cites W2005601959 @default.
- W2326059418 cites W2008647280 @default.
- W2326059418 cites W2011993186 @default.
- W2326059418 cites W2012372919 @default.
- W2326059418 cites W2014279251 @default.
- W2326059418 cites W2017042541 @default.
- W2326059418 cites W2018130645 @default.
- W2326059418 cites W2018551075 @default.
- W2326059418 cites W2020789296 @default.
- W2326059418 cites W2021123830 @default.
- W2326059418 cites W2023975842 @default.
- W2326059418 cites W2035543796 @default.
- W2326059418 cites W2036334396 @default.
- W2326059418 cites W2038211177 @default.
- W2326059418 cites W2044998777 @default.
- W2326059418 cites W2056821544 @default.
- W2326059418 cites W2057152418 @default.
- W2326059418 cites W2061654588 @default.
- W2326059418 cites W2062393611 @default.
- W2326059418 cites W2062813263 @default.
- W2326059418 cites W2063091609 @default.
- W2326059418 cites W2064200890 @default.
- W2326059418 cites W2065531348 @default.
- W2326059418 cites W2070809717 @default.
- W2326059418 cites W2079592358 @default.
- W2326059418 cites W2080776248 @default.
- W2326059418 cites W2084821192 @default.
- W2326059418 cites W2087689337 @default.
- W2326059418 cites W2087964639 @default.
- W2326059418 cites W2088585261 @default.
- W2326059418 cites W2090477854 @default.
- W2326059418 cites W2092373383 @default.
- W2326059418 cites W2098060422 @default.
- W2326059418 cites W2101497968 @default.
- W2326059418 cites W2101554740 @default.
- W2326059418 cites W2103801717 @default.
- W2326059418 cites W2103903744 @default.
- W2326059418 cites W2104658942 @default.
- W2326059418 cites W2104904180 @default.
- W2326059418 cites W2116837559 @default.
- W2326059418 cites W2119933811 @default.
- W2326059418 cites W2120048439 @default.
- W2326059418 cites W2120494409 @default.
- W2326059418 cites W2124715997 @default.
- W2326059418 cites W2134210839 @default.
- W2326059418 cites W2134800079 @default.
- W2326059418 cites W2138270253 @default.
- W2326059418 cites W2139436376 @default.
- W2326059418 cites W2140023356 @default.
- W2326059418 cites W2140206817 @default.
- W2326059418 cites W2140683734 @default.
- W2326059418 cites W2140897574 @default.
- W2326059418 cites W2141497413 @default.
- W2326059418 cites W2143682738 @default.
- W2326059418 cites W2143841198 @default.
- W2326059418 cites W2145144163 @default.
- W2326059418 cites W2145922766 @default.
- W2326059418 cites W2151726995 @default.
- W2326059418 cites W2154729337 @default.
- W2326059418 cites W2158804451 @default.
- W2326059418 cites W2162327089 @default.
- W2326059418 cites W2164422164 @default.
- W2326059418 cites W2166036382 @default.
- W2326059418 cites W2170315275 @default.
- W2326059418 cites W2182185778 @default.
- W2326059418 cites W2230764959 @default.
- W2326059418 cites W2327226362 @default.
- W2326059418 cites W2333708805 @default.
- W2326059418 cites W2334667596 @default.
- W2326059418 cites W2417874084 @default.
- W2326059418 cites W2421508336 @default.