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- W2326059431 abstract "Myc oncoproteins regulate transcription by binding to target genes harboring E-boxes or Initiator elements, yet these responses explain only a fraction of the genes Myc affects. mRNA turnover is controlled via binding of AU-binding proteins (AUBPs) to AU-rich elements (AREs) found within many transcripts. Expression analyses of precancerous and malignant Myc-expressing B cells revealed Myc regulates hundreds of ARE-containing genes and several AUBPs. Notably, Myc directly suppresses transcription of Tristetraprolin (TTP), an mRNA-destabilizing AUBP, and TTP suppression is a hallmark of Myc-driven lymphoma in mice and man. Furthermore, TTP has profound effects on tumorigenesis, where restoring TTP impairs Myc-induced lymphoma development and abolishes maintenance of the malignant state; thus, TTP functions as a tumor suppressor. Finally, the Myc-to-TTP pathway regulates a very select cast of ARE-containing genes that control cell proliferation and transformation. Thus, Myc utilizes AUBPs to target ARE-containing genes in its efforts to control cell fate and transformation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4027. doi:10.1158/1538-7445.AM2011-4027" @default.
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- W2326059431 date "2011-04-15" @default.
- W2326059431 modified "2023-09-27" @default.
- W2326059431 title "Abstract 4027: Myc controls mRNA stability through the agency of AU-binding proteins to promote lymphomagenesis" @default.
- W2326059431 doi "https://doi.org/10.1158/1538-7445.am2011-4027" @default.
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