Matches in SemOpenAlex for { <https://semopenalex.org/work/W2326111624> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2326111624 endingPage "985" @default.
- W2326111624 startingPage "978" @default.
- W2326111624 abstract "Based on the structures of the tubulin-colchicine binding site and ligands, a series of new 3D pharmacophore models (M1-M6) were constructed by using a new module in the molecular modeling software Discovery Studio, version 3.0. After validated by 20 known tubulin inhibitors, one of the new pharmacophore models (M1) was used to screen about 10000 compounds and discovered some potential lead compounds. A synthesized diaryamine compound 20, one the of predicted potential leads, was tested in human chronic myelogenous leukemia (K562) cell line, resulting in obviously inhibitory activity and morphologic change on cellularity. Compound 20 also exhibited high potency in the human tumor cell line panel (A549, KB, KBvin and DU145) with a GI50 value range from 0.17 to 1.02 μmol/L. Therefore, these results indicate that the new 3D-pharmacophore model could serve as a useful tool to search and rationally design new anticancer agents that target the tubulin-colchicine binding site." @default.
- W2326111624 created "2016-06-24" @default.
- W2326111624 creator A5010642871 @default.
- W2326111624 creator A5020312424 @default.
- W2326111624 creator A5034252403 @default.
- W2326111624 date "2011-10-01" @default.
- W2326111624 modified "2023-10-16" @default.
- W2326111624 title "A New 3D-pharmacophore Model Based on Tubulin-colchicine Binding Site and Ligands for Virtual Screening of New Leads" @default.
- W2326111624 doi "https://doi.org/10.1360/052011-606" @default.
- W2326111624 hasPublicationYear "2011" @default.
- W2326111624 type Work @default.
- W2326111624 sameAs 2326111624 @default.
- W2326111624 citedByCount "0" @default.
- W2326111624 crossrefType "journal-article" @default.
- W2326111624 hasAuthorship W2326111624A5010642871 @default.
- W2326111624 hasAuthorship W2326111624A5020312424 @default.
- W2326111624 hasAuthorship W2326111624A5034252403 @default.
- W2326111624 hasConcept C103697762 @default.
- W2326111624 hasConcept C107824862 @default.
- W2326111624 hasConcept C12554922 @default.
- W2326111624 hasConcept C185592680 @default.
- W2326111624 hasConcept C20418707 @default.
- W2326111624 hasConcept C21951064 @default.
- W2326111624 hasConcept C2776636253 @default.
- W2326111624 hasConcept C41008148 @default.
- W2326111624 hasConcept C54355233 @default.
- W2326111624 hasConcept C55493867 @default.
- W2326111624 hasConcept C56173144 @default.
- W2326111624 hasConcept C70721500 @default.
- W2326111624 hasConcept C71240020 @default.
- W2326111624 hasConcept C84425145 @default.
- W2326111624 hasConcept C86803240 @default.
- W2326111624 hasConcept C95444343 @default.
- W2326111624 hasConceptScore W2326111624C103697762 @default.
- W2326111624 hasConceptScore W2326111624C107824862 @default.
- W2326111624 hasConceptScore W2326111624C12554922 @default.
- W2326111624 hasConceptScore W2326111624C185592680 @default.
- W2326111624 hasConceptScore W2326111624C20418707 @default.
- W2326111624 hasConceptScore W2326111624C21951064 @default.
- W2326111624 hasConceptScore W2326111624C2776636253 @default.
- W2326111624 hasConceptScore W2326111624C41008148 @default.
- W2326111624 hasConceptScore W2326111624C54355233 @default.
- W2326111624 hasConceptScore W2326111624C55493867 @default.
- W2326111624 hasConceptScore W2326111624C56173144 @default.
- W2326111624 hasConceptScore W2326111624C70721500 @default.
- W2326111624 hasConceptScore W2326111624C71240020 @default.
- W2326111624 hasConceptScore W2326111624C84425145 @default.
- W2326111624 hasConceptScore W2326111624C86803240 @default.
- W2326111624 hasConceptScore W2326111624C95444343 @default.
- W2326111624 hasIssue "10" @default.
- W2326111624 hasLocation W23261116241 @default.
- W2326111624 hasOpenAccess W2326111624 @default.
- W2326111624 hasPrimaryLocation W23261116241 @default.
- W2326111624 hasRelatedWork W1966813923 @default.
- W2326111624 hasRelatedWork W2034914503 @default.
- W2326111624 hasRelatedWork W2136206204 @default.
- W2326111624 hasRelatedWork W2329091253 @default.
- W2326111624 hasRelatedWork W2799327292 @default.
- W2326111624 hasRelatedWork W3143016362 @default.
- W2326111624 hasRelatedWork W3210534360 @default.
- W2326111624 hasRelatedWork W4297977790 @default.
- W2326111624 hasRelatedWork W4309796337 @default.
- W2326111624 hasRelatedWork W2576653714 @default.
- W2326111624 hasVolume "41" @default.
- W2326111624 isParatext "false" @default.
- W2326111624 isRetracted "false" @default.
- W2326111624 magId "2326111624" @default.
- W2326111624 workType "article" @default.