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• W2326134472 abstract "<h3>Background</h3> Biologics (BIO) have been developed the treatment of rheumatoid arthritis represent a remarkable advance over and beyond the conventional disease-modifying antirheumatic drugs (cDMARDs)¹. However, 20–30% of rheumatoid arthritis (RA) patients using biologics are nonresponders or show only minor improvement. <h3>Objectives</h3> Recently it was reported the concentration of serum cytokine was related the response of treatment for RA^2,3. We investigate the relationships of it before taking first BIO and the change of disease activity in our series. <h3>Methods</h3> One hundred nighty-nine RA patients have received BIO in our institutes from 2004 to 2013. Forty-one patients in BIO naive cases (infliximab 16 cases, etanercept 13, tocilizumab 9, adalimumab 3) were examined the concentration of serum tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta, IL-6 before receiving first BIO by ELISA. They are estimated the transition of disease activity score (DAS)28/C-reactive protein (CRP) score (4) and clinical disease activity index (CDAI) one year after first BIO. They are 7 men and thirty-four women. Their mean age is 55 years (range 32-74), mean duration of RA affliction was 7.8 years (1-22). <h3>Results</h3> The mean concentration of serum TNF-alpha and IL-beta, IL-6 was 16.2 (0.6-238) pg/ml,; 10 (10-11); 34.1 (0.5-303) before first BIO, respectively. The mean CRP levels, DAS28-CRP (4) and CDAI were 29 g/dl (range, 1–82), 4.9 (1.0-7.2) and 24.8 (0-67) before first BIO, which improved as 7 (0-34) g/dl, 3.1 (10-64) and 10.3 (0-30) one year after first BIO, respectively. EULAR response criteria were used, and there was a good response in twenty-eight patients (68%), a moderate response in eight (20%) and no response in five (12%), respectively, during the treatment period starting at the commencement of the BIO and one year after. Only the value of serum IL-6 was significantly related to the results of EULAR response and CRP before first BIO (p<0.05, Fig. 1). Four case in good response group was satisfied of criteria of remission using CDAI scoring (<2.8). <h3>Conclusions</h3> The value of serum IL-6 before receiving BIO seems to have the potential marker for predicting the response of BIO treatment in RA patients. <h3>References</h3> Klareskog L, et al: Lancet 2004; 363:675-681. Takeuchi T, et al: ARD 2012; 71: 1583-1585. Shimamoto K, et al: J Rheumatol 2013; 40:1074-1081. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.3522" @default.
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• W2326134472 date "2014-06-01" @default.
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• W2326134472 title "AB0091 The Concentration of Serum Interleukin-6 before Biologic Treatment Are Related to Clinical Response in the Patients of Rheumatoid Arthritis" @default.
• W2326134472 doi "https://doi.org/10.1136/annrheumdis-2014-eular.3522" @default.
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