Matches in SemOpenAlex for { <https://semopenalex.org/work/W2326161572> ?p ?o ?g. }
- W2326161572 endingPage "3111" @default.
- W2326161572 startingPage "3103" @default.
- W2326161572 abstract "The human serine/threonine kinase Aurora-B is structurally related to the protein kinase Ipl1p from S cerevisiae and aurora from Drosophila melanogaster, which are key regulators of mitosis. The present study shows that human Aurora-B is activated by okadaic acid and forms complexes with the protein serine/threonine phosphatase type 1 (PP1) or PP2A, but not with PP5. These data identified Aurora-B associated protein phosphatases as negative regulators of kinase activation. We then used a series of substrates based on a histone H3 phosphorylation site (residues 5-15) to determine the substrate specificity of human Aurora-B. We found that this enzyme is an arginine-directed kinase that can phosphorylate histone H3 at serines 10 and 28 in vitro, suggesting that human Aurora-B is a mitotic histone H3 kinase." @default.
- W2326161572 created "2016-06-24" @default.
- W2326161572 creator A5001962229 @default.
- W2326161572 creator A5013218910 @default.
- W2326161572 creator A5032775705 @default.
- W2326161572 creator A5037589641 @default.
- W2326161572 creator A5037850937 @default.
- W2326161572 creator A5047776373 @default.
- W2326161572 creator A5053529984 @default.
- W2326161572 creator A5065769442 @default.
- W2326161572 creator A5088043523 @default.
- W2326161572 date "2002-05-07" @default.
- W2326161572 modified "2023-09-26" @default.
- W2326161572 title "Aurora-B associated protein phosphatases as negative regulators of kinase activation" @default.
- W2326161572 cites W1504478980 @default.
- W2326161572 cites W1573255988 @default.
- W2326161572 cites W1886278373 @default.
- W2326161572 cites W1942192923 @default.
- W2326161572 cites W1966219754 @default.
- W2326161572 cites W1973704051 @default.
- W2326161572 cites W1989394815 @default.
- W2326161572 cites W1998544890 @default.
- W2326161572 cites W2002698073 @default.
- W2326161572 cites W2009876130 @default.
- W2326161572 cites W2015956088 @default.
- W2326161572 cites W2019571270 @default.
- W2326161572 cites W2033141310 @default.
- W2326161572 cites W2035881741 @default.
- W2326161572 cites W2038638713 @default.
- W2326161572 cites W2045987477 @default.
- W2326161572 cites W2048109276 @default.
- W2326161572 cites W2048843865 @default.
- W2326161572 cites W2052764579 @default.
- W2326161572 cites W2054091018 @default.
- W2326161572 cites W2055203805 @default.
- W2326161572 cites W2060387110 @default.
- W2326161572 cites W2061805545 @default.
- W2326161572 cites W2066607735 @default.
- W2326161572 cites W2069910776 @default.
- W2326161572 cites W2079067261 @default.
- W2326161572 cites W2084264782 @default.
- W2326161572 cites W2094900302 @default.
- W2326161572 cites W2108408221 @default.
- W2326161572 cites W2125624250 @default.
- W2326161572 cites W2133263108 @default.
- W2326161572 cites W2137429755 @default.
- W2326161572 cites W2141599538 @default.
- W2326161572 cites W2143658931 @default.
- W2326161572 cites W2146686648 @default.
- W2326161572 cites W214799791 @default.
- W2326161572 cites W2305334404 @default.
- W2326161572 cites W4243666696 @default.
- W2326161572 cites W4251055596 @default.
- W2326161572 cites W4295216797 @default.
- W2326161572 doi "https://doi.org/10.1038/sj.onc.1205432" @default.
- W2326161572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12082625" @default.
- W2326161572 hasPublicationYear "2002" @default.
- W2326161572 type Work @default.
- W2326161572 sameAs 2326161572 @default.
- W2326161572 citedByCount "140" @default.
- W2326161572 countsByYear W23261615722012 @default.
- W2326161572 countsByYear W23261615722013 @default.
- W2326161572 countsByYear W23261615722014 @default.
- W2326161572 countsByYear W23261615722015 @default.
- W2326161572 countsByYear W23261615722016 @default.
- W2326161572 countsByYear W23261615722017 @default.
- W2326161572 countsByYear W23261615722018 @default.
- W2326161572 countsByYear W23261615722019 @default.
- W2326161572 countsByYear W23261615722020 @default.
- W2326161572 countsByYear W23261615722021 @default.
- W2326161572 countsByYear W23261615722023 @default.
- W2326161572 crossrefType "journal-article" @default.
- W2326161572 hasAuthorship W2326161572A5001962229 @default.
- W2326161572 hasAuthorship W2326161572A5013218910 @default.
- W2326161572 hasAuthorship W2326161572A5032775705 @default.
- W2326161572 hasAuthorship W2326161572A5037589641 @default.
- W2326161572 hasAuthorship W2326161572A5037850937 @default.
- W2326161572 hasAuthorship W2326161572A5047776373 @default.
- W2326161572 hasAuthorship W2326161572A5053529984 @default.
- W2326161572 hasAuthorship W2326161572A5065769442 @default.
- W2326161572 hasAuthorship W2326161572A5088043523 @default.
- W2326161572 hasBestOaLocation W23261615721 @default.
- W2326161572 hasConcept C104317684 @default.
- W2326161572 hasConcept C11960822 @default.
- W2326161572 hasConcept C124160383 @default.
- W2326161572 hasConcept C137361374 @default.
- W2326161572 hasConcept C141937037 @default.
- W2326161572 hasConcept C1491633281 @default.
- W2326161572 hasConcept C159479382 @default.
- W2326161572 hasConcept C20552341 @default.
- W2326161572 hasConcept C2776745794 @default.
- W2326161572 hasConcept C29537977 @default.
- W2326161572 hasConcept C45472230 @default.
- W2326161572 hasConcept C55493867 @default.
- W2326161572 hasConcept C59143045 @default.
- W2326161572 hasConcept C64927066 @default.
- W2326161572 hasConcept C82495950 @default.
- W2326161572 hasConcept C85813293 @default.