FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2326163944> ?p ?o ?g. }

• W2326163944 endingPage "2698" @default.
• W2326163944 startingPage "2691" @default.
• W2326163944 abstract "Mechanisms of partial unfolding and aggregation of proteins are of extreme interest in view of the fact that several human pathologies are characterized by the formation and deposition of protein-insoluble material, mainly composed of amyloid fibrils. Here we report on an experimental study on the heat-induced aggregation mechanisms, at basic pH, of concanavalin A (ConA), used as a model system. Thioflavin T (ThT) fluorescence and multiangle light scattering allowed us to detect different intertwined steps in the formation of ConA aggregates. In particular, the ThT fluorescence increase, observed in the first phase of aggregation, reveals the formation of intermolecular β-sheet structure which constitutes a rate-limiting step of the process. The intertwining between the formation of β-aggregate structures and the whole aggregation process is discussed as a function of protein concentration: a coagulation process produces the same kind of aggregates at the different concentrations studied. Multiangle light-scattering data highlight the onset of the condensation process which gives rise to formation of compact fractal aggregates. AFM microscopy supports this conclusion showing thin fibrils of ConA, formed in the early stage of aggregation, which further interact to form larger structures with a netlike spatial organization." @default.
• W2326163944 created "2016-06-24" @default.
• W2326163944 creator A5008409588 @default.
• W2326163944 creator A5024210312 @default.
• W2326163944 creator A5027061305 @default.
• W2326163944 creator A5053725102 @default.
• W2326163944 creator A5075057620 @default.
• W2326163944 creator A5075303499 @default.
• W2326163944 date "2011-03-10" @default.
• W2326163944 modified "2023-09-27" @default.
• W2326163944 title "Amyloid Fibrils Formation of Concanavalin A at Basic pH" @default.
• W2326163944 cites W1481393922 @default.
• W2326163944 cites W1483264458 @default.
• W2326163944 cites W1585586097 @default.
• W2326163944 cites W1856532105 @default.
• W2326163944 cites W1973897761 @default.
• W2326163944 cites W1977082872 @default.
• W2326163944 cites W1979613917 @default.
• W2326163944 cites W1998056625 @default.
• W2326163944 cites W1998440525 @default.
• W2326163944 cites W2001559730 @default.
• W2326163944 cites W2005217073 @default.
• W2326163944 cites W2005842673 @default.
• W2326163944 cites W2009404855 @default.
• W2326163944 cites W2012455318 @default.
• W2326163944 cites W2014027303 @default.
• W2326163944 cites W2024895112 @default.
• W2326163944 cites W2028204954 @default.
• W2326163944 cites W2028953659 @default.
• W2326163944 cites W2037580706 @default.
• W2326163944 cites W2042036635 @default.
• W2326163944 cites W2042413457 @default.
• W2326163944 cites W2051301360 @default.
• W2326163944 cites W2057709942 @default.
• W2326163944 cites W2060890430 @default.
• W2326163944 cites W2070380111 @default.
• W2326163944 cites W2078211100 @default.
• W2326163944 cites W2082501707 @default.
• W2326163944 cites W2083014787 @default.
• W2326163944 cites W2087840002 @default.
• W2326163944 cites W2121753059 @default.
• W2326163944 cites W2133822720 @default.
• W2326163944 cites W2134220277 @default.
• W2326163944 cites W2139644513 @default.
• W2326163944 cites W2242536402 @default.
• W2326163944 doi "https://doi.org/10.1021/jp1042409" @default.
• W2326163944 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21391626" @default.
• W2326163944 hasPublicationYear "2011" @default.
• W2326163944 type Work @default.
• W2326163944 sameAs 2326163944 @default.
• W2326163944 citedByCount "22" @default.
• W2326163944 countsByYear W23261639442012 @default.
• W2326163944 countsByYear W23261639442013 @default.
• W2326163944 countsByYear W23261639442014 @default.
• W2326163944 countsByYear W23261639442015 @default.
• W2326163944 countsByYear W23261639442016 @default.
• W2326163944 countsByYear W23261639442017 @default.
• W2326163944 countsByYear W23261639442018 @default.
• W2326163944 countsByYear W23261639442020 @default.
• W2326163944 crossrefType "journal-article" @default.
• W2326163944 hasAuthorship W2326163944A5008409588 @default.
• W2326163944 hasAuthorship W2326163944A5024210312 @default.
• W2326163944 hasAuthorship W2326163944A5027061305 @default.
• W2326163944 hasAuthorship W2326163944A5053725102 @default.
• W2326163944 hasAuthorship W2326163944A5075057620 @default.
• W2326163944 hasAuthorship W2326163944A5075303499 @default.
• W2326163944 hasConcept C120456961 @default.
• W2326163944 hasConcept C120665830 @default.
• W2326163944 hasConcept C121332964 @default.
• W2326163944 hasConcept C12554922 @default.
• W2326163944 hasConcept C136238340 @default.
• W2326163944 hasConcept C142724271 @default.
• W2326163944 hasConcept C14631669 @default.
• W2326163944 hasConcept C155672457 @default.
• W2326163944 hasConcept C171250308 @default.
• W2326163944 hasConcept C179104552 @default.
• W2326163944 hasConcept C185592680 @default.
• W2326163944 hasConcept C191486275 @default.
• W2326163944 hasConcept C192441466 @default.
• W2326163944 hasConcept C192562407 @default.
• W2326163944 hasConcept C19869320 @default.
• W2326163944 hasConcept C202751555 @default.
• W2326163944 hasConcept C27523624 @default.
• W2326163944 hasConcept C2777633098 @default.
• W2326163944 hasConcept C2778896982 @default.
• W2326163944 hasConcept C2779134260 @default.
• W2326163944 hasConcept C2994168385 @default.
• W2326163944 hasConcept C3019447875 @default.
• W2326163944 hasConcept C502032728 @default.
• W2326163944 hasConcept C55493867 @default.
• W2326163944 hasConcept C71924100 @default.
• W2326163944 hasConcept C8010536 @default.
• W2326163944 hasConcept C86803240 @default.
• W2326163944 hasConcept C91881484 @default.
• W2326163944 hasConcept C98239406 @default.
• W2326163944 hasConceptScore W2326163944C120456961 @default.
• W2326163944 hasConceptScore W2326163944C120665830 @default.
• W2326163944 hasConceptScore W2326163944C121332964 @default.

• next