FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2326187533> ?p ?o ?g. }

• W2326187533 abstract "Calcific aortic stenosis (AS) is the most prevalent heart valve disorder in developed countries. It is characterized by progressive fibro-calcific remodelling and thickening of the aortic valve leaflets that, over years, evolve to cause severe obstruction to cardiac outflow. In developed countries, AS is the third-most frequent cardiovascular disease after coronary artery disease and systemic arterial hypertension, with a prevalence of 0.4% in the general population and 1.7% in the population >65 years old. Congenital abnormality (bicuspid valve) and older age are powerful risk factors for calcific AS. Metabolic syndrome and an elevated plasma level of lipoprotein(a) have also been associated with increased risk of calcific AS. The pathobiology of calcific AS is complex and involves genetic factors, lipoprotein deposition and oxidation, chronic inflammation, osteoblastic transition of cardiac valve interstitial cells and active leaflet calcification. Although no pharmacotherapy has proved to be effective in reducing the progression of AS, promising therapeutic targets include lipoprotein(a), the renin–angiotensin system, receptor activator of NF-κB ligand (RANKL; also known as TNFSF11) and ectonucleotidases. Currently, aortic valve replacement (AVR) remains the only effective treatment for severe AS. The diagnosis and staging of AS are based on the assessment of stenosis severity and left ventricular systolic function by Doppler echocardiography, and the presence of symptoms. The introduction of transcatheter AVR in the past decade has been a transformative therapeutic innovation for patients at high or prohibitive risk for surgical valve replacement, and this new technology might extend to lower-risk patients in the near future. Calcific aortic stenosis (AS) involves fibro-calcific remodelling of the aortic valve that causes restriction of blood flow. Pibarot and colleagues discuss the mechanisms, diagnosis and management of AS and highlight how the introduction of transcatheter-based valve replacement has transformed patient outcomes." @default.
• W2326187533 created "2016-06-24" @default.
• W2326187533 creator A5001026049 @default.
• W2326187533 creator A5009728510 @default.
• W2326187533 creator A5021922273 @default.
• W2326187533 creator A5034995895 @default.
• W2326187533 creator A5048504581 @default.
• W2326187533 creator A5063272468 @default.
• W2326187533 creator A5071026604 @default.
• W2326187533 date "2016-03-03" @default.
• W2326187533 modified "2023-10-18" @default.
• W2326187533 title "Calcific aortic stenosis" @default.
• W2326187533 cites W147713215 @default.
• W2326187533 cites W1507413178 @default.
• W2326187533 cites W154700364 @default.
• W2326187533 cites W155024021 @default.
• W2326187533 cites W1560998933 @default.
• W2326187533 cites W1575075233 @default.
• W2326187533 cites W1609565130 @default.
• W2326187533 cites W161548076 @default.
• W2326187533 cites W1641844203 @default.
• W2326187533 cites W1656248607 @default.
• W2326187533 cites W170643099 @default.
• W2326187533 cites W173091792 @default.
• W2326187533 cites W1905115184 @default.
• W2326187533 cites W1915791432 @default.
• W2326187533 cites W1921637439 @default.
• W2326187533 cites W1923019781 @default.
• W2326187533 cites W193780144 @default.
• W2326187533 cites W1946105702 @default.
• W2326187533 cites W1948348644 @default.
• W2326187533 cites W195414628 @default.
• W2326187533 cites W195442482 @default.
• W2326187533 cites W1955064660 @default.
• W2326187533 cites W195680333 @default.
• W2326187533 cites W1963647443 @default.
• W2326187533 cites W1964471691 @default.
• W2326187533 cites W1965115186 @default.
• W2326187533 cites W1965381743 @default.
• W2326187533 cites W1965887353 @default.
• W2326187533 cites W1966839457 @default.
• W2326187533 cites W196764548 @default.
• W2326187533 cites W1969332989 @default.
• W2326187533 cites W1971540719 @default.
• W2326187533 cites W1972254695 @default.
• W2326187533 cites W1972433143 @default.
• W2326187533 cites W1973241413 @default.
• W2326187533 cites W1974857224 @default.
• W2326187533 cites W1976669848 @default.
• W2326187533 cites W1977991799 @default.
• W2326187533 cites W1978366710 @default.
• W2326187533 cites W1979649623 @default.
• W2326187533 cites W1980676714 @default.
• W2326187533 cites W1981305717 @default.
• W2326187533 cites W1983114604 @default.
• W2326187533 cites W1983692570 @default.
• W2326187533 cites W1984323565 @default.
• W2326187533 cites W1984363220 @default.
• W2326187533 cites W1987880059 @default.
• W2326187533 cites W1988482331 @default.
• W2326187533 cites W1990343804 @default.
• W2326187533 cites W1991215013 @default.
• W2326187533 cites W1992419135 @default.
• W2326187533 cites W1992728554 @default.
• W2326187533 cites W1993384753 @default.
• W2326187533 cites W1994568523 @default.
• W2326187533 cites W1994703716 @default.
• W2326187533 cites W1995437010 @default.
• W2326187533 cites W1996132619 @default.
• W2326187533 cites W1996617143 @default.
• W2326187533 cites W1997576072 @default.
• W2326187533 cites W1997660486 @default.
• W2326187533 cites W1998280774 @default.
• W2326187533 cites W1998409913 @default.
• W2326187533 cites W1998979687 @default.
• W2326187533 cites W2000180001 @default.
• W2326187533 cites W2000385072 @default.
• W2326187533 cites W2004452013 @default.
• W2326187533 cites W2004967032 @default.
• W2326187533 cites W2005313664 @default.
• W2326187533 cites W2007320747 @default.
• W2326187533 cites W2008166400 @default.
• W2326187533 cites W2008513872 @default.
• W2326187533 cites W2008576197 @default.
• W2326187533 cites W2009592273 @default.
• W2326187533 cites W2009936845 @default.
• W2326187533 cites W2010890329 @default.
• W2326187533 cites W2012876291 @default.
• W2326187533 cites W2013354092 @default.
• W2326187533 cites W2014225480 @default.
• W2326187533 cites W2020797302 @default.
• W2326187533 cites W2022051990 @default.
• W2326187533 cites W2022126825 @default.
• W2326187533 cites W2022348836 @default.
• W2326187533 cites W2023616993 @default.
• W2326187533 cites W2025529577 @default.
• W2326187533 cites W2028139616 @default.
• W2326187533 cites W2028435096 @default.
• W2326187533 cites W2032514624 @default.
• W2326187533 cites W2033528683 @default.

• next