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• W2326190995 abstract "Background: The objective of this study was to compare the osteogenic potential of reinforced and conventional tissue-engineered periosteum. Methods: Adipose-derived stromal cells of rabbits were induced into osteoblasts. Osteoinduced cells were seeded onto chitosan-tricalcium phosphate-gelatin (Cs-TCP-Gel) and chitosan (Cs) scaffold, thus constructing the reinforced and conventional tissue-engineered periostea, respectively. Alkaline phosphatase (ALP) and von Kossa staining protocols were used to assess osteoblast phenotype. We surgically created a 15-mm-long bone defect in the right radii of New Zealand rabbits. The defects were treated with reinforced biomimetic periosteum in group A (n = 30) and treated with conventional tissue-engineered periosteum in group B (n = 30). Group C (n = 30) received CS-TCP-Gel scaffold alone, and group D (n = 30) served as untreated side (sham group). Radiologic, histologic, immunohistochemical, and histomorphometric studies were used to analyze healing pattern. Results: ALP was remarkably expressed in the osteoinduced cells, indicating that osteoblastic differentiation was stable. Extracellular matrix calcification with dark nodule was detected by von Kossa staining. Compared with groups B and C, histologic results demonstrated that de novo osteogenesis proliferated in group A at 4 weeks. This was further confirmed by radiographic findings, which displayed the segmental gap completely healed by mature bone at 12 weeks. Robust expression of bone morphogenetic protein-2 in group A was also evident, whereas group D displayed poor osteogenic performance. Furthermore, histomorphometric and biomechanical results in group A demonstrated statistical significance over those in other groups (p < 0.05). Conclusions: Our findings show that the reinforced tissue-engineered periosteum is superior to conventional one as a better biomimetic tissue, further indicating that it can repair the weight-bearing defects." @default.
• W2326190995 created "2016-06-24" @default.
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• W2326190995 date "2012-02-01" @default.
• W2326190995 modified "2023-09-22" @default.
• W2326190995 title "Reconstruction of radial bone defects using the reinforced tissue-engineered periosteum" @default.
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• W2326190995 doi "https://doi.org/10.1097/ta.0b013e3182196a54" @default.
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