Matches in SemOpenAlex for { <https://semopenalex.org/work/W2326231714> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2326231714 endingPage "541" @default.
- W2326231714 startingPage "541" @default.
- W2326231714 abstract "Introduction: Valganciclovir is the most common drug used for cytomegalovirus (CMV) prophylaxis at present. Nevertheless, also the efficacy of high-dose valacyclovir was documented in randomized trials together with reduced risk of acute rejection. There is no head-to-head comparison of both drugs. Methods: A total of 99 renal transplant recipients at risk for CMV (D+/R−, D+/R+, D−/R+) were randomized to 3-month prophylaxis either with valganciclovir (900mg once daily, n=50) or valacyclovir (2g four times daily, n=49). Quantitative PCR for CMV DNA in whole blood was assessed every second week for 3 months and at 4, 5, 6, 9 and 12 months. Results: The 12-month incidence of CMV viremia was comparable (31% vs. 42%, P=0.205) in the valganciclovir and valacyclovir groups, respectively. The incidence of CMV disease was low and not different (2% vs. 2%, P=0.958). A numerically lower rate of biopsy-proven acute rejection during 12 months was observed in valganciclovir treated patients (16% vs. 26%), however the difference did not reach statistical significance (P=0.264). Conclusions: Valganciclovir and valacyclovir prophylaxis are equally effective in the prevention of CMV disease after renal transplantation. A trend toward higher rate of acute rejection with valacyclovir prophylaxis requires further investigation." @default.
- W2326231714 created "2016-06-24" @default.
- W2326231714 creator A5006403773 @default.
- W2326231714 creator A5010494320 @default.
- W2326231714 creator A5045150707 @default.
- W2326231714 creator A5067801650 @default.
- W2326231714 creator A5068758499 @default.
- W2326231714 date "2012-11-01" @default.
- W2326231714 modified "2023-09-25" @default.
- W2326231714 title "The 2VAL Study: Randomized Comparison of Valganciclovir Vs. Valacyclovir for Cytomegalovirus Prophylaxis after Renal Transplantation" @default.
- W2326231714 doi "https://doi.org/10.1097/00007890-201211271-01043" @default.
- W2326231714 hasPublicationYear "2012" @default.
- W2326231714 type Work @default.
- W2326231714 sameAs 2326231714 @default.
- W2326231714 citedByCount "0" @default.
- W2326231714 crossrefType "journal-article" @default.
- W2326231714 hasAuthorship W2326231714A5006403773 @default.
- W2326231714 hasAuthorship W2326231714A5010494320 @default.
- W2326231714 hasAuthorship W2326231714A5045150707 @default.
- W2326231714 hasAuthorship W2326231714A5067801650 @default.
- W2326231714 hasAuthorship W2326231714A5068758499 @default.
- W2326231714 hasBestOaLocation W23262317141 @default.
- W2326231714 hasConcept C120665830 @default.
- W2326231714 hasConcept C121332964 @default.
- W2326231714 hasConcept C126322002 @default.
- W2326231714 hasConcept C141071460 @default.
- W2326231714 hasConcept C168563851 @default.
- W2326231714 hasConcept C203014093 @default.
- W2326231714 hasConcept C2522874641 @default.
- W2326231714 hasConcept C2776317777 @default.
- W2326231714 hasConcept C2776409557 @default.
- W2326231714 hasConcept C2777732132 @default.
- W2326231714 hasConcept C2777965375 @default.
- W2326231714 hasConcept C2779820661 @default.
- W2326231714 hasConcept C2780727368 @default.
- W2326231714 hasConcept C2911091166 @default.
- W2326231714 hasConcept C61511704 @default.
- W2326231714 hasConcept C71924100 @default.
- W2326231714 hasConcept C90924648 @default.
- W2326231714 hasConceptScore W2326231714C120665830 @default.
- W2326231714 hasConceptScore W2326231714C121332964 @default.
- W2326231714 hasConceptScore W2326231714C126322002 @default.
- W2326231714 hasConceptScore W2326231714C141071460 @default.
- W2326231714 hasConceptScore W2326231714C168563851 @default.
- W2326231714 hasConceptScore W2326231714C203014093 @default.
- W2326231714 hasConceptScore W2326231714C2522874641 @default.
- W2326231714 hasConceptScore W2326231714C2776317777 @default.
- W2326231714 hasConceptScore W2326231714C2776409557 @default.
- W2326231714 hasConceptScore W2326231714C2777732132 @default.
- W2326231714 hasConceptScore W2326231714C2777965375 @default.
- W2326231714 hasConceptScore W2326231714C2779820661 @default.
- W2326231714 hasConceptScore W2326231714C2780727368 @default.
- W2326231714 hasConceptScore W2326231714C2911091166 @default.
- W2326231714 hasConceptScore W2326231714C61511704 @default.
- W2326231714 hasConceptScore W2326231714C71924100 @default.
- W2326231714 hasConceptScore W2326231714C90924648 @default.
- W2326231714 hasIssue "10S" @default.
- W2326231714 hasLocation W23262317141 @default.
- W2326231714 hasOpenAccess W2326231714 @default.
- W2326231714 hasPrimaryLocation W23262317141 @default.
- W2326231714 hasRelatedWork W1817881132 @default.
- W2326231714 hasRelatedWork W1992736476 @default.
- W2326231714 hasRelatedWork W1996182916 @default.
- W2326231714 hasRelatedWork W1996922568 @default.
- W2326231714 hasRelatedWork W2004766863 @default.
- W2326231714 hasRelatedWork W2096634389 @default.
- W2326231714 hasRelatedWork W2129588868 @default.
- W2326231714 hasRelatedWork W2317819115 @default.
- W2326231714 hasRelatedWork W2385743273 @default.
- W2326231714 hasRelatedWork W2403317366 @default.
- W2326231714 hasVolume "94" @default.
- W2326231714 isParatext "false" @default.
- W2326231714 isRetracted "false" @default.
- W2326231714 magId "2326231714" @default.
- W2326231714 workType "article" @default.