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• W2326279958 abstract "Conformational restriction of the pyrrolidine nitrogen in nicotine by the introduction of an ethylene bridge provided a potent and selective antagonist of the α4β2-subtype of the nicotinic acetylcholine receptors. Resolution by chiral SFC, pharmacological characterization of the two enantiomers, and determination of absolute configuration via enantioselective synthesis showed that the pharmacological activity resided almost exclusively in the (R)-enantiomer." @default.
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• W2326279958 date "2015-03-06" @default.
• W2326279958 modified "2023-10-14" @default.
• W2326279958 title "Tying up Nicotine: New Selective Competitive Antagonist of the Neuronal Nicotinic Acetylcholine Receptors" @default.
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• W2326279958 doi "https://doi.org/10.1021/acsmedchemlett.5b00028" @default.
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