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- W2326314484 abstract "Linear alkylbenzene sulfonate (LAS) was applied dermally to pregnant mice in order to examine the embryotoxic and teratogenic effects. In ICR-JCL strain mice, LAS was given once daily at 0.5ml per mouse as 0.85, 1.7, 2.55, and 3.4% solutions from day 1 to 13 of gestation, and in ddY strain mice as 0.017, 0.17, and 1.7% solutions from day 2 to 14 of gestation. The results obtained were summarized as follows:1. Neither suppression of body weight gain nor visceral defects of the dams were observed in all the groups tested. However, the reduced rate of pregnancy was observed in 3.4% group, in which considerable skin irritation was seen at the applied site.2. Slight growth suppression of live fetuses in ICR-JCL mice were observed in 0.85, 2.55, and 3.4% groups. No significant difference between the applied and the control groups was found in external and internal abnormalities of the fetuses.3. The retarded ossification of sternebrae in ICR-JCL mouse fetuses were observed more frequently in both groups of 2.55 and 3.4% compared with the control. No skeletal abnormalities, assumed to be caused by the application of LAS, were observed in all groups.The results of this study would suggest that there was no conclusive evidence of teratogenic effects, assumed to be originated from LAS application, even at high concentrations." @default.
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- W2326314484 date "1974-01-01" @default.
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- W2326314484 title "Effects of Linear Alkylbenzene Sulfonate Applied Dermally to Pregnant Mice on the Development of Their Fetuses" @default.
- W2326314484 doi "https://doi.org/10.3358/shokueishi.15.349" @default.
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