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- W2326374920 endingPage "84" @default.
- W2326374920 startingPage "76" @default.
- W2326374920 abstract "The advent of targeted oncolytic agents has created a revolution in the treatment of malignancies. Perhaps best exemplified in myeloproliferative neoplasms (MPN), the tyrosine kinase inhibitors, including inhibitors of BCR-ABL tyrosine kinase and JAK2, have dramatically changed outcomes in persons with MPN. However, clinically relevant dosing of these adenosine triphosphate-mimetic agents in humans leads to inhibition of numerous tyrosine kinases beyond those touted by drug manufacturers and studied in landmark clinical trials. These so-called off-target effects have been linked to both clinical efficacy and toxicity. Rational drug development and serendipitous discovery of drug molecules allows the clinician to select targeted oncolytic agents to treat a specific clinical diagnosis and/or avoid exacerbation of concomitant disease states due to effects upon signaling pathways. Understanding the off-target binding and effects upon signaling pathway of the agents approved for the treatment of MPN will empower the clinician to adroitly select pharmacotherapy, predict toxicities, and utilize these agents in clinical practice for indications beyond MPN." @default.
- W2326374920 created "2016-06-24" @default.
- W2326374920 creator A5042596451 @default.
- W2326374920 creator A5059831890 @default.
- W2326374920 creator A5091892222 @default.
- W2326374920 date "2016-02-01" @default.
- W2326374920 modified "2023-09-30" @default.
- W2326374920 title "Off-Target Effects of BCR-ABL and JAK2 Inhibitors" @default.
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