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- W2326386723 abstract "Using low-frequency ultrasound to increase the permeability of human skin, researchers at Massachusetts Institute of Technology have induced proteins to pass the barrier. The work by chemical engineers Samir Mitragotri, Daniel E. Blankschtein, and Robert S. Langer opens the possibility of transdermal delivery of therapeutic proteins to treat diabetes, anemia, and cancer, among other diseases [Science, 269, 850 (1995)] Transdermal delivery offers several advantages over traditional drug delivery methods. It avoids the pain injections can cause and the gastrointestinal degradation some drugs can cause when taken orally. And transdermal delivery using skin patches provides sustained release over several days. Because of skin's low permeability, only a handful of hydrophobic, low molecular weight drugs—including estradiol, nicotine, and nitroglycerine—can be administered transdermally. These drugs enter the bloodstream via slow, passive diffusion along the lipid bilayers surrounding the keratin fiber-f..." @default.
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- W2326386723 date "1995-08-14" @default.
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- W2326386723 title "Ultrasound opens skin barrier to proteins" @default.
- W2326386723 doi "https://doi.org/10.1021/cen-v073n033.p005a" @default.
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