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- W2326468267 abstract "Two closely associated components were detected by immunoelectrophoresis in the serum macroglobulin response of mice to Ascaris suum. One of these components was demonstrated to be IgM. The second component was shown to be antigenically distinct from IgM by rabbit antisera made to the macroglobulin fraction of infected mouse sera or to antigen-antibody precipitates of ascaris extract and mouse serum. The second component was not detected in normal mouse serum or in sera from mice with a variety of parasitic infections. This component bound to ascaris extract and its presence coincided with precipitin formation in agar gel between ascaris extract and sera from infected mice. Preliminary studies failed to establish that this component was an immunoglobulin or an acute phase reactant. The possible nature of the component is discussed. Helminth infections commonly induce raised serum immunoglobulin levels and a complex antibody response (Smithers, 1967). Larval ascarid infections in man have been associated with hypergammaglobulinemia with an increased level of IgM (Huntley et al., 1965). In a previous study, a precipitating antibody of the IgM immunoglobulin class was demonstrated in the sera of mice following experimental infection with Ascaris suum (Crandall and Crandall, 1967). Gel elution profiles, as well as immunoelectrophoretic studies of serum from mice, suggested that a marked increase in the concentration of macroglobulins occurred after an infection with A. suum. The present investigation was initiated to characterize further this macroglobulin response to larval A. suum infection in mice. MATERIALS AND METHODS" @default.
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- W2326468267 date "1969-10-01" @default.
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- W2326468267 title "Macroglobulin Antibody Response to Ascaris suum Infection. Detection of a Second Macroglobulin Component in the Serum of Infected Mice" @default.
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- W2326468267 doi "https://doi.org/10.2307/3277169" @default.
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