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- W2326468908 abstract "HIV PathogenesisHIV-1 replicates well in humans but not in monkeys or mice. On the up side, this reduces the risk of cross-species transmissions, but it makes the study of HIV-1 and AIDS more difficult. Hatziioannou et al. overcame this hurdle by serially passaging HIV-1 in pigtailed macaques. Over time, the HIV-1 acquired mutations that allowed it to adapt to the monkeys. Depleting CD8+ T cells during acute infection resulted in a subset of animals developing an AIDS-like disease by the fourth passage. HIV-1 envelope protein gene selection and the acquisition of mutations in the HIV protein Vpu, which allowed HIV-1 to overcome host restriction by the macaque protein tetherin, accompanied the viral adaptation to the monkeys.Science , this issue p. [1401][1] [1]: /lookup/doi/10.1126/science.1250761" @default.
- W2326468908 created "2016-06-24" @default.
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- W2326468908 date "2014-06-19" @default.
- W2326468908 modified "2023-09-24" @default.
- W2326468908 title "Adapting HIV-1 to infect monkeys, too" @default.
- W2326468908 doi "https://doi.org/10.1126/science.344.6190.1354-o" @default.
- W2326468908 hasPublicationYear "2014" @default.
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