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- W2326478906 abstract "83 Patient history: 36 year old homosexual male with HIV diagnosis from 1993. In August 1994 he had cerebral toxoplamosis, initially eradicated and put on suppressive therapy. CMV-retinitis was diagnosed in February 1995, treated with alternating foscarnet and gancyclovir until May 1997 when foscarnet was withdrawn. Antiretroviral therapy was initiated during March 1996 with AZT and DDI and switched to triple combination with AZT, 3 TC and indinavir (proteasinhibitor) in September 1996. The CD4 cell count, originally 30 × 106/l (8%), then increased to 160 × 106/l / (24%). HIV-RNA-PCR was negative ( <500 copies /ml ). In August 1997 the patient got lactatdehydrogenas(LD) elevation and night sweats and a month later ascites. On CTscan a mass was shown in the gastric wall. Cytological analysis of cells recovered from the ascitic fluid showed a population of dispersed large blastic cells with a high frequency of mitoses and partly vacuolated dark blue cytoplasm, reminiscent of lymphoblasts. Immunocytochemically the tumor cells where positive for CD 4 and weakly positive for CD22 as well as CD30.In the cytological material a few EBV-LMP 1 positive tumor cells where seen. Histological examination of a core biopsy from the gastric mass showed a soft tissue infiltration of the same tumor cell population. Cytostatic treatment (CHOP and intrathecal methotrexat) was initiated on October 13 and the ascites disappeared within 4 days. In November 1997 the patient was doing well on cytostatic and antiretroviral treatment, working halftime. The future treatment will be discussed, as well as quantitative EBV in B-cells and quantitative HIV-RNA will be presented." @default.
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- W2326478906 date "1998-04-01" @default.
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- W2326478906 title "Body cavity based lymphoma (BCBL) in an AIDS-patient during successful triple antiretroviral therapy - treatment and outcome." @default.
- W2326478906 doi "https://doi.org/10.1097/00042560-199804010-00098" @default.
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