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- W2326491503 abstract "The prothrombin activity in plasma was highly correlated with that in liver in normal rats, bishydroxycoumarin (dicumarol)-treated rats and CCl4-treated rats. Menaquinone-4(K2(20)) significantly increased the prothrombin activities in plasma and in liver of rats which had hypoprothrombinemia induced by administration of dicumarol or CCl4. K2(20) significantly promoted the prothrombin synthesis in liver homogenate in the rats treated with dicumarol or CCl4. Furthermore, it was observed that K2(20) exerted a promoting effect on prothrombin synthesis in the microsomal fraction of liver. However, when plasma was incubated with K2(20), the prothrombin time of the plasma was not shortened. The effects of K2(20) on the prothrombin activity and on the prothrombin synthesis of liver were more rapid and stronger than those of vitamin K1. It is concluded that K2(20) promotes prothrombin synthesis in liver parenchymal cells and improves hypoprothrombinemia caused by dicumarol or CCl4 in rats." @default.
- W2326491503 created "2016-06-24" @default.
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- W2326491503 date "1975-01-01" @default.
- W2326491503 modified "2023-09-23" @default.
- W2326491503 title "Mode of action of menaquinone-4 on blood coagulation." @default.
- W2326491503 doi "https://doi.org/10.1248/cpb.23.1943" @default.
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- W2326491503 hasPublicationYear "1975" @default.
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