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- W2326492039 abstract "In a within-patient crossover study on twelve patients we investigated plasma morphine concentrations for 48 hours after administration of intravenous morphine sulphate followed 24 hours later by oral MST Continus [MST]. Patients received either 10 mg i.v. morphine followed by 10 mg MST or 20 mg i.v. morphine followed by 2×10 mg MST tablets. Systemic clearance of morphine was low, being about 3 ml/min/kg after both intravenous and oral administration. The ratio of the areas under the concentration–time curve for MST relative to that for i.v. morphine was about 1:1 for 20 mg doses, but was significantly greater than 1:1 for 10 mg doses. The results suggest high oral systemic availability for morphine and low hepatic morphine metabolism." @default.
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- W2326492039 date "1985-05-01" @default.
- W2326492039 modified "2023-09-27" @default.
- W2326492039 title "Systemic Availability of Oral Slow-Release Morphine in Man" @default.
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- W2326492039 doi "https://doi.org/10.1177/000456328502200303" @default.
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