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• W2326493009 abstract "Paclitaxel, an expensive first-line anticancer drug, is known to have better pharmacokinetics and therapeutic efficacy if encapsulated in polymeric micelles. However, the conventional encapsulation methods using incompressible aqueous solutions are limited to low drug loading, less than 3% of micelle weight, and low efficiency, more than two-thirds of the drug in solution remains unencapsulated, and hence wasted, not to mention the burst release problems. This work demonstrates that expansion of near-critical fluid solutions, for example in compressible dimethyl ether and trifluoromethane not too far from their critical region, can lead to a much higher drug loading, for example in micelles formed from poly(ethylene glycol)-block-poly(ε-caprolactone) (PEG-b-PCL). By controlling the drug precipitation within the micellar solution region, the loading of paclitaxel in PEG-b-PCL can reach over 12% with a loading efficiency of 87%, which is unattainable by conventional methods. Moreover, the burst release fraction of the drug can be reduced despite the higher drug loading. This means that the new near-critical fluid micellization (NCFM) method will allow not only for a lower exposure of the body to the copolymer at the same treatment drug rate, due to the high drug loading, but also for less waste of the expensive drug, due to the high efficiency." @default.
• W2326493009 created "2016-06-24" @default.
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• W2326493009 date "2011-05-25" @default.
• W2326493009 modified "2023-10-03" @default.
• W2326493009 title "Near-Critical Fluid Micellization for High and Efficient Drug Loading: Encapsulation of Paclitaxel into PEG-<i>b</i>-PCL Micelles" @default.
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• W2326493009 doi "https://doi.org/10.1021/jp202335r" @default.
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