Matches in SemOpenAlex for { <https://semopenalex.org/work/W2326501908> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2326501908 endingPage "A31" @default.
- W2326501908 startingPage "A31" @default.
- W2326501908 abstract "<h3>Introduction</h3> Determining factors in the causal pathway between an exposure and a disease is often the aim of etiologic research. For example, if a gene is associated with a certain disease, one would like to know if this relation can be explained by one or more intermediary variables. A naive approach to explore this is to condition on the intermediate factor and perform a stratified analysis. However, when an association remains, it is not always clear how this should be interpreted. It may be explained by a true direct effect of the exposure on the disease, or it may be explained by different types of error. <h3>Methods</h3> We study different situations, using directed acyclic graphs, where despite absence of a direct effect, still a conditional relation between the exposure and the outcome remains. By quantifying the effect on the association parameter in each of the situations, we develop tools for sensitivity analysis of the completeness of adjusting for a mediator. The performance of the sensitivity tools is studied by simulation and by applying the tools on data of the LETS study. In this case-control study the question was whether the relation between blood group and venous thrombosis was mediated through coagulation factor VIII. <h3>Results</h3> A remaining association can be caused by different types of measurement error, reverse causation or unmeasured confounding. In the LETS study intra-individual variation explained most of the remaining association. <h3>Conclusion</h3> Sensitivity analyses should be performed before the conclusion is made that effects are not completely mediated." @default.
- W2326501908 created "2016-06-24" @default.
- W2326501908 creator A5008174194 @default.
- W2326501908 creator A5013389478 @default.
- W2326501908 creator A5046574211 @default.
- W2326501908 creator A5091666538 @default.
- W2326501908 creator A5048073753 @default.
- W2326501908 date "2011-08-01" @default.
- W2326501908 modified "2023-09-27" @default.
- W2326501908 title "O3-1.3 Sensitivity analysis for an apparent direct effect after conditioning on an intermediate variable" @default.
- W2326501908 doi "https://doi.org/10.1136/jech.2011.142976a.84" @default.
- W2326501908 hasPublicationYear "2011" @default.
- W2326501908 type Work @default.
- W2326501908 sameAs 2326501908 @default.
- W2326501908 citedByCount "0" @default.
- W2326501908 crossrefType "journal-article" @default.
- W2326501908 hasAuthorship W2326501908A5008174194 @default.
- W2326501908 hasAuthorship W2326501908A5013389478 @default.
- W2326501908 hasAuthorship W2326501908A5046574211 @default.
- W2326501908 hasAuthorship W2326501908A5048073753 @default.
- W2326501908 hasAuthorship W2326501908A5091666538 @default.
- W2326501908 hasBestOaLocation W23265019081 @default.
- W2326501908 hasConcept C105795698 @default.
- W2326501908 hasConcept C111472728 @default.
- W2326501908 hasConcept C121332964 @default.
- W2326501908 hasConcept C124101348 @default.
- W2326501908 hasConcept C126322002 @default.
- W2326501908 hasConcept C127413603 @default.
- W2326501908 hasConcept C138885662 @default.
- W2326501908 hasConcept C142853389 @default.
- W2326501908 hasConcept C166151441 @default.
- W2326501908 hasConcept C17744445 @default.
- W2326501908 hasConcept C199539241 @default.
- W2326501908 hasConcept C21200559 @default.
- W2326501908 hasConcept C24326235 @default.
- W2326501908 hasConcept C25343380 @default.
- W2326501908 hasConcept C2780011451 @default.
- W2326501908 hasConcept C2780868729 @default.
- W2326501908 hasConcept C33923547 @default.
- W2326501908 hasConcept C40696583 @default.
- W2326501908 hasConcept C41008148 @default.
- W2326501908 hasConcept C62520636 @default.
- W2326501908 hasConcept C64357122 @default.
- W2326501908 hasConcept C71924100 @default.
- W2326501908 hasConcept C77350462 @default.
- W2326501908 hasConceptScore W2326501908C105795698 @default.
- W2326501908 hasConceptScore W2326501908C111472728 @default.
- W2326501908 hasConceptScore W2326501908C121332964 @default.
- W2326501908 hasConceptScore W2326501908C124101348 @default.
- W2326501908 hasConceptScore W2326501908C126322002 @default.
- W2326501908 hasConceptScore W2326501908C127413603 @default.
- W2326501908 hasConceptScore W2326501908C138885662 @default.
- W2326501908 hasConceptScore W2326501908C142853389 @default.
- W2326501908 hasConceptScore W2326501908C166151441 @default.
- W2326501908 hasConceptScore W2326501908C17744445 @default.
- W2326501908 hasConceptScore W2326501908C199539241 @default.
- W2326501908 hasConceptScore W2326501908C21200559 @default.
- W2326501908 hasConceptScore W2326501908C24326235 @default.
- W2326501908 hasConceptScore W2326501908C25343380 @default.
- W2326501908 hasConceptScore W2326501908C2780011451 @default.
- W2326501908 hasConceptScore W2326501908C2780868729 @default.
- W2326501908 hasConceptScore W2326501908C33923547 @default.
- W2326501908 hasConceptScore W2326501908C40696583 @default.
- W2326501908 hasConceptScore W2326501908C41008148 @default.
- W2326501908 hasConceptScore W2326501908C62520636 @default.
- W2326501908 hasConceptScore W2326501908C64357122 @default.
- W2326501908 hasConceptScore W2326501908C71924100 @default.
- W2326501908 hasConceptScore W2326501908C77350462 @default.
- W2326501908 hasIssue "Suppl 1" @default.
- W2326501908 hasLocation W23265019081 @default.
- W2326501908 hasOpenAccess W2326501908 @default.
- W2326501908 hasPrimaryLocation W23265019081 @default.
- W2326501908 hasRelatedWork W1972803014 @default.
- W2326501908 hasRelatedWork W2001709765 @default.
- W2326501908 hasRelatedWork W2014011059 @default.
- W2326501908 hasRelatedWork W2027061482 @default.
- W2326501908 hasRelatedWork W2094448630 @default.
- W2326501908 hasRelatedWork W2120451602 @default.
- W2326501908 hasRelatedWork W3038540718 @default.
- W2326501908 hasRelatedWork W3130830546 @default.
- W2326501908 hasRelatedWork W4255351298 @default.
- W2326501908 hasRelatedWork W4310713667 @default.
- W2326501908 hasVolume "65" @default.
- W2326501908 isParatext "false" @default.
- W2326501908 isRetracted "false" @default.
- W2326501908 magId "2326501908" @default.
- W2326501908 workType "article" @default.