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- W2326517382 abstract "RGD-PEG-GNRs facilitate specific targeting of integrin αvβ6 that is selectively overexpressed in head and neck cancer, including HSC3. The GNRs were internalized to endosome and lysosomal vesicles through attaching to the cytoplasmic membrane. We further showed that facilitating RGD-PEG-GNR uptake in cancer cells significantly enhanced their radiosensitivity and thus increased DNA damage. In vivo distribution revealed significant accumulation of the RGD-PEG-GNRs in tumor tissues as compared to other major organs. Such tumor lesion accumulation peaked at 12 h followed by a decline over time. In the RESs, the liver is the major organ for RGD-PEG-GNR accumulation followed by the lung and then the spleen. Our results encouraged further development of RGD-PEG-GNR-augmented megavoltage radiation therapy and potential integration with chemotherapy targeting molecular mechanisms of DNA damage repair." @default.
- W2326517382 created "2016-06-24" @default.
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- W2326517382 date "2016-03-01" @default.
- W2326517382 modified "2023-09-24" @default.
- W2326517382 title "Integrin Targeted Gold Nanoparticles Potentiate Cancer Radiation Sensitivity: Synthesizing and modifying gold nanorods to target cancer cells" @default.
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- W2326517382 doi "https://doi.org/10.1109/mnano.2015.2507191" @default.
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