FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2326518551> ?p ?o ?g. }

• W2326518551 endingPage "845" @default.
• W2326518551 startingPage "839" @default.
• W2326518551 abstract "Cytomegalovirus (CMV) infection is an ongoing clinical problem in solid-organ transplantation (SOT). Pretransplant CMV serology is currently the only tool for assessing the risk of CMV infection, although cellular immune responses driven by CMV-specific CD4 and CD8 T lymphocytes are important for controlling viral replication. Therefore, the analysis of CMV-specific T cells may be useful for estimating the risk of infection.This is a prospective study of patients with kidney transplants and no prophylactic treatment for CMV replication. CD4 and CD8 T-cell responses to the major CMV pp65 and IE-1 antigens in 15 seropositive patients at intermediate risk of CMV infection were investigated, according to current algorithms. Intracellular flow cytometry was employed to determine IFN-γ production as a functional readout. The response was analyzed in pretransplant samples and prospectively at 1 and 6 months and at 1 year posttransplant.It was observed that the CD8 responses to IE-1 antigen were practically absent pretransplant in patients who developed CMV infection posttransplant. Within the group of patients free of infection, CD8 responses to IE-1 were detected more frequently and were significantly higher (P=0.0083). In a receiver operating characteristics curve analysis (AUC=0.929; P=0.010; 95% CI: 0.078-1.0), low CD8 responses to IE-1 (≤0.05%) pretransplant predicted the development of CMV infection under the immunosuppressive regime after transplant with 100% specificity and 85.7% sensitivity.Assessment of IE-1-specific CD8 T-cell frequencies pretransplant may be a useful tool for identifying seropositive SOT patients at risk of developing CMV infection posttransplant." @default.
• W2326518551 created "2016-06-24" @default.
• W2326518551 creator A5013433043 @default.
• W2326518551 creator A5016398785 @default.
• W2326518551 creator A5021349611 @default.
• W2326518551 creator A5024051115 @default.
• W2326518551 creator A5040092217 @default.
• W2326518551 creator A5052858320 @default.
• W2326518551 creator A5061039664 @default.
• W2326518551 creator A5088945477 @default.
• W2326518551 creator A5089462896 @default.
• W2326518551 date "2014-04-27" @default.
• W2326518551 modified "2023-10-17" @default.
• W2326518551 title "Pretransplant CD8 T-Cell Response to IE-1 Discriminates Seropositive Kidney Recipients at Risk of Developing CMV Infection Posttransplant" @default.
• W2326518551 cites W1586769637 @default.
• W2326518551 cites W1605479195 @default.
• W2326518551 cites W1708437872 @default.
• W2326518551 cites W1810287099 @default.
• W2326518551 cites W1966858455 @default.
• W2326518551 cites W1979907315 @default.
• W2326518551 cites W1992047047 @default.
• W2326518551 cites W1994888472 @default.
• W2326518551 cites W1996573297 @default.
• W2326518551 cites W1999421885 @default.
• W2326518551 cites W2021355833 @default.
• W2326518551 cites W2039802707 @default.
• W2326518551 cites W2053901884 @default.
• W2326518551 cites W2064286842 @default.
• W2326518551 cites W2099400163 @default.
• W2326518551 cites W2116311749 @default.
• W2326518551 cites W2120759748 @default.
• W2326518551 cites W2126658764 @default.
• W2326518551 cites W2135945048 @default.
• W2326518551 cites W2137644534 @default.
• W2326518551 cites W2140647949 @default.
• W2326518551 cites W2147567613 @default.
• W2326518551 cites W2148223163 @default.
• W2326518551 cites W2156951291 @default.
• W2326518551 cites W2157709400 @default.
• W2326518551 cites W2168744744 @default.
• W2326518551 cites W4211083670 @default.
• W2326518551 doi "https://doi.org/10.1097/01.tp.0000438025.96334.eb" @default.
• W2326518551 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24345896" @default.
• W2326518551 hasPublicationYear "2014" @default.
• W2326518551 type Work @default.
• W2326518551 sameAs 2326518551 @default.
• W2326518551 citedByCount "34" @default.
• W2326518551 countsByYear W23265185512014 @default.
• W2326518551 countsByYear W23265185512015 @default.
• W2326518551 countsByYear W23265185512016 @default.
• W2326518551 countsByYear W23265185512017 @default.
• W2326518551 countsByYear W23265185512018 @default.
• W2326518551 countsByYear W23265185512019 @default.
• W2326518551 countsByYear W23265185512020 @default.
• W2326518551 countsByYear W23265185512021 @default.
• W2326518551 countsByYear W23265185512022 @default.
• W2326518551 crossrefType "journal-article" @default.
• W2326518551 hasAuthorship W2326518551A5013433043 @default.
• W2326518551 hasAuthorship W2326518551A5016398785 @default.
• W2326518551 hasAuthorship W2326518551A5021349611 @default.
• W2326518551 hasAuthorship W2326518551A5024051115 @default.
• W2326518551 hasAuthorship W2326518551A5040092217 @default.
• W2326518551 hasAuthorship W2326518551A5052858320 @default.
• W2326518551 hasAuthorship W2326518551A5061039664 @default.
• W2326518551 hasAuthorship W2326518551A5088945477 @default.
• W2326518551 hasAuthorship W2326518551A5089462896 @default.
• W2326518551 hasBestOaLocation W23265185511 @default.
• W2326518551 hasConcept C126322002 @default.
• W2326518551 hasConcept C142462285 @default.
• W2326518551 hasConcept C147483822 @default.
• W2326518551 hasConcept C159047783 @default.
• W2326518551 hasConcept C159654299 @default.
• W2326518551 hasConcept C167672396 @default.
• W2326518551 hasConcept C203014093 @default.
• W2326518551 hasConcept C2522874641 @default.
• W2326518551 hasConcept C2776090121 @default.
• W2326518551 hasConcept C2776409557 @default.
• W2326518551 hasConcept C2777662283 @default.
• W2326518551 hasConcept C2777732132 @default.
• W2326518551 hasConcept C2779820661 @default.
• W2326518551 hasConcept C2780303639 @default.
• W2326518551 hasConcept C2780727368 @default.
• W2326518551 hasConcept C2911091166 @default.
• W2326518551 hasConcept C45189115 @default.
• W2326518551 hasConcept C553184892 @default.
• W2326518551 hasConcept C71924100 @default.
• W2326518551 hasConcept C8891405 @default.
• W2326518551 hasConceptScore W2326518551C126322002 @default.
• W2326518551 hasConceptScore W2326518551C142462285 @default.
• W2326518551 hasConceptScore W2326518551C147483822 @default.
• W2326518551 hasConceptScore W2326518551C159047783 @default.
• W2326518551 hasConceptScore W2326518551C159654299 @default.
• W2326518551 hasConceptScore W2326518551C167672396 @default.
• W2326518551 hasConceptScore W2326518551C203014093 @default.
• W2326518551 hasConceptScore W2326518551C2522874641 @default.
• W2326518551 hasConceptScore W2326518551C2776090121 @default.
• W2326518551 hasConceptScore W2326518551C2776409557 @default.
• W2326518551 hasConceptScore W2326518551C2777662283 @default.

• next