Matches in SemOpenAlex for { <https://semopenalex.org/work/W2326527636> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2326527636 endingPage "538" @default.
- W2326527636 startingPage "531" @default.
- W2326527636 abstract "A gas chromatographic-mass spectrometric (GC/MS) method for the determination of β-{3-oxo-s-triazolo[4, 3a]pyridin-3(2H)-one}-propionic acid (TPA), a metabolite of trazodone hydrochloride, in biological fluids has been developed. Deuterated analogue of TPA was used as an internal standard. TPA was extracted with ethyl acetate from plasma and urine, and derivatized into a pentafluorobenzyl ester. The reaction mixture was further purified by high-performance liquid chromatography on a reversed-phase column. The eluent containing pentafluorobenzyl ester of TPA and deuterated TPA was collected, and extracted with benzene. GC/MS was carried out by monitoring the molecular ions. The determination limit was 500 pg/ml, and the intra and inter-assay coefficients of variation for the determination of TPA in plasma were 6.7 ?? 9.4% and 7.3 ?? 11.5%, respectively. Plasma levels and urinary excretion were determined by the present method for five healthy volunteers who had received a 50 mg oral dose of trazodone hydrochloride." @default.
- W2326527636 created "2016-06-24" @default.
- W2326527636 creator A5011781447 @default.
- W2326527636 creator A5022729681 @default.
- W2326527636 creator A5036866876 @default.
- W2326527636 creator A5084336507 @default.
- W2326527636 date "1987-01-01" @default.
- W2326527636 modified "2023-09-23" @default.
- W2326527636 title "Quantitative determination of .BETA.-{3-oxo-s-triazolo(4, 3a)pyridin-3(2H)-one}-propionic acid(TPA), a metabolite of trazodone hydrochloride, in plasma and urine by gas chromatography-mass spectrometry." @default.
- W2326527636 cites W1973163530 @default.
- W2326527636 cites W1980585492 @default.
- W2326527636 cites W2013524482 @default.
- W2326527636 cites W2042813627 @default.
- W2326527636 cites W2049532415 @default.
- W2326527636 cites W2055713909 @default.
- W2326527636 cites W2066305381 @default.
- W2326527636 cites W2066965699 @default.
- W2326527636 cites W2073445258 @default.
- W2326527636 cites W2079012548 @default.
- W2326527636 cites W2113975131 @default.
- W2326527636 cites W2117137041 @default.
- W2326527636 cites W2155021817 @default.
- W2326527636 cites W23344674 @default.
- W2326527636 cites W56235217 @default.
- W2326527636 cites W2395165885 @default.
- W2326527636 doi "https://doi.org/10.2133/dmpk.2.531" @default.
- W2326527636 hasPublicationYear "1987" @default.
- W2326527636 type Work @default.
- W2326527636 sameAs 2326527636 @default.
- W2326527636 citedByCount "0" @default.
- W2326527636 crossrefType "journal-article" @default.
- W2326527636 hasAuthorship W2326527636A5011781447 @default.
- W2326527636 hasAuthorship W2326527636A5022729681 @default.
- W2326527636 hasAuthorship W2326527636A5036866876 @default.
- W2326527636 hasAuthorship W2326527636A5084336507 @default.
- W2326527636 hasBestOaLocation W23265276361 @default.
- W2326527636 hasConcept C119128265 @default.
- W2326527636 hasConcept C123460561 @default.
- W2326527636 hasConcept C162356407 @default.
- W2326527636 hasConcept C169760540 @default.
- W2326527636 hasConcept C178790620 @default.
- W2326527636 hasConcept C179302884 @default.
- W2326527636 hasConcept C185592680 @default.
- W2326527636 hasConcept C205345274 @default.
- W2326527636 hasConcept C2776460385 @default.
- W2326527636 hasConcept C2777477808 @default.
- W2326527636 hasConcept C2779177272 @default.
- W2326527636 hasConcept C2780026642 @default.
- W2326527636 hasConcept C2780980600 @default.
- W2326527636 hasConcept C2781161787 @default.
- W2326527636 hasConcept C43617362 @default.
- W2326527636 hasConcept C55493867 @default.
- W2326527636 hasConcept C86803240 @default.
- W2326527636 hasConceptScore W2326527636C119128265 @default.
- W2326527636 hasConceptScore W2326527636C123460561 @default.
- W2326527636 hasConceptScore W2326527636C162356407 @default.
- W2326527636 hasConceptScore W2326527636C169760540 @default.
- W2326527636 hasConceptScore W2326527636C178790620 @default.
- W2326527636 hasConceptScore W2326527636C179302884 @default.
- W2326527636 hasConceptScore W2326527636C185592680 @default.
- W2326527636 hasConceptScore W2326527636C205345274 @default.
- W2326527636 hasConceptScore W2326527636C2776460385 @default.
- W2326527636 hasConceptScore W2326527636C2777477808 @default.
- W2326527636 hasConceptScore W2326527636C2779177272 @default.
- W2326527636 hasConceptScore W2326527636C2780026642 @default.
- W2326527636 hasConceptScore W2326527636C2780980600 @default.
- W2326527636 hasConceptScore W2326527636C2781161787 @default.
- W2326527636 hasConceptScore W2326527636C43617362 @default.
- W2326527636 hasConceptScore W2326527636C55493867 @default.
- W2326527636 hasConceptScore W2326527636C86803240 @default.
- W2326527636 hasIssue "5" @default.
- W2326527636 hasLocation W23265276361 @default.
- W2326527636 hasOpenAccess W2326527636 @default.
- W2326527636 hasPrimaryLocation W23265276361 @default.
- W2326527636 hasRelatedWork W1946147279 @default.
- W2326527636 hasRelatedWork W1990694197 @default.
- W2326527636 hasRelatedWork W2021585491 @default.
- W2326527636 hasRelatedWork W2032997490 @default.
- W2326527636 hasRelatedWork W2033940602 @default.
- W2326527636 hasRelatedWork W2038114176 @default.
- W2326527636 hasRelatedWork W2046070614 @default.
- W2326527636 hasRelatedWork W2079996778 @default.
- W2326527636 hasRelatedWork W2373875332 @default.
- W2326527636 hasRelatedWork W2394771821 @default.
- W2326527636 hasVolume "2" @default.
- W2326527636 isParatext "false" @default.
- W2326527636 isRetracted "false" @default.
- W2326527636 magId "2326527636" @default.
- W2326527636 workType "article" @default.