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- W2326538589 abstract "Pancreatic cancers are classified as either exocrine or endocrine tumors depending on which type of tissue they arise from within the gland. Endocrine tumors of the pancreas are very rare, accounting for only 5% of all pancreatic cancers. The majority of endocrine pancreatic tumors are functional adenocarcinomas that overproduce a specific hormone. Pancreatic cancer is a devastating disease and has an extremely poor prognosis. Most patients die within a year of diagnosis and the overall 5-year survival rate is <1% despite the use of extensive treatment approaches, including surgery, chemotherapy, and radiation. Therefore, innovative anti-tumor therapies for this group of patients is of a great significance. Recent preclinical and clinical studies demonstrated that immunotherapy, in particular vaccination with dendritic cells (DCs) loaded with tumor antigens, is a potential approach with promising anti-tumor effects. Therefore, augmenting the efficacy of immunotherapy with DCs would significantly improve the health of this group of patients. One strategy to augment DC-based vaccination is the use of potent adjuvants that can induce the full activation and maturation of the injected antigen-loaded DCs and their migration to the tumor draining lymph nodes, the site of antigen recognition by T cells. One of the most potent adjuvants is the microbial products that are recognized by more than 13 toll-like receptors expressed on DCs. This review article will highlight the use of DC-based vaccination toward pancreatic cancer and how it can be augmented by toll-like receptor agonists." @default.
- W2326538589 created "2016-06-24" @default.
- W2326538589 creator A5018009812 @default.
- W2326538589 date "2009-12-01" @default.
- W2326538589 modified "2023-09-22" @default.
- W2326538589 title "The Potential use of Dendritic Cell-based Immunotherapy for Treatment of Pancreatic Cancer" @default.
- W2326538589 cites W114561417 @default.
- W2326538589 cites W146554869 @default.
- W2326538589 cites W1484698145 @default.
- W2326538589 cites W1488760070 @default.
- W2326538589 cites W1497407552 @default.
- W2326538589 cites W1506811134 @default.
- W2326538589 cites W1510907154 @default.
- W2326538589 cites W1522206763 @default.
- W2326538589 cites W1529036199 @default.
- W2326538589 cites W1534928966 @default.
- W2326538589 cites W1548018585 @default.
- W2326538589 cites W1585317227 @default.
- W2326538589 cites W1599928841 @default.
- W2326538589 cites W1606468448 @default.
- W2326538589 cites W1661544713 @default.
- W2326538589 cites W1800111497 @default.
- W2326538589 cites W1842585496 @default.
- W2326538589 cites W1879131976 @default.
- W2326538589 cites W1927092294 @default.
- W2326538589 cites W1931508686 @default.
- W2326538589 cites W1948870183 @default.
- W2326538589 cites W1964545356 @default.
- W2326538589 cites W1965404729 @default.
- W2326538589 cites W1966233007 @default.
- W2326538589 cites W1968619878 @default.
- W2326538589 cites W1969238175 @default.
- W2326538589 cites W1969989221 @default.
- W2326538589 cites W1972107031 @default.
- W2326538589 cites W1972621450 @default.
- W2326538589 cites W1973251492 @default.
- W2326538589 cites W1974315687 @default.
- W2326538589 cites W1974320608 @default.
- W2326538589 cites W1977732271 @default.
- W2326538589 cites W1977906128 @default.
- W2326538589 cites W1983954483 @default.
- W2326538589 cites W1987520066 @default.
- W2326538589 cites W1987815488 @default.
- W2326538589 cites W1988604479 @default.
- W2326538589 cites W1990206605 @default.
- W2326538589 cites W1990893332 @default.
- W2326538589 cites W1992314477 @default.
- W2326538589 cites W1993597307 @default.
- W2326538589 cites W1999220701 @default.
- W2326538589 cites W2000253004 @default.
- W2326538589 cites W2000274253 @default.
- W2326538589 cites W2000286082 @default.
- W2326538589 cites W2000751577 @default.
- W2326538589 cites W2001653425 @default.
- W2326538589 cites W2003211608 @default.
- W2326538589 cites W2004792081 @default.
- W2326538589 cites W2004911979 @default.
- W2326538589 cites W2005067757 @default.
- W2326538589 cites W2005381406 @default.
- W2326538589 cites W2006783667 @default.
- W2326538589 cites W2006801909 @default.
- W2326538589 cites W2007968203 @default.
- W2326538589 cites W2008606789 @default.
- W2326538589 cites W2008700756 @default.
- W2326538589 cites W2011834818 @default.
- W2326538589 cites W2013686456 @default.
- W2326538589 cites W2014748782 @default.
- W2326538589 cites W2018105460 @default.
- W2326538589 cites W2021021710 @default.
- W2326538589 cites W2021265838 @default.
- W2326538589 cites W2022890571 @default.
- W2326538589 cites W2024506919 @default.
- W2326538589 cites W2024759932 @default.
- W2326538589 cites W2027804050 @default.
- W2326538589 cites W2028167622 @default.
- W2326538589 cites W203051214 @default.
- W2326538589 cites W2031608952 @default.
- W2326538589 cites W2031745114 @default.
- W2326538589 cites W2031747611 @default.
- W2326538589 cites W2033415145 @default.
- W2326538589 cites W2033914239 @default.
- W2326538589 cites W2035563280 @default.
- W2326538589 cites W2035809809 @default.
- W2326538589 cites W2035831579 @default.
- W2326538589 cites W2036711926 @default.
- W2326538589 cites W2037225657 @default.
- W2326538589 cites W2039262417 @default.
- W2326538589 cites W2039613171 @default.
- W2326538589 cites W2042121895 @default.
- W2326538589 cites W2043875007 @default.
- W2326538589 cites W2044399538 @default.
- W2326538589 cites W2044567178 @default.
- W2326538589 cites W2046663003 @default.
- W2326538589 cites W2046804345 @default.
- W2326538589 cites W2049698602 @default.
- W2326538589 cites W2052669146 @default.
- W2326538589 cites W2054129665 @default.
- W2326538589 cites W2055790683 @default.
- W2326538589 cites W2056033102 @default.
- W2326538589 cites W2059864992 @default.