Matches in SemOpenAlex for { <https://semopenalex.org/work/W2326551727> ?p ?o ?g. }
- W2326551727 endingPage "523" @default.
- W2326551727 startingPage "514" @default.
- W2326551727 abstract "Although the phototoxic and photoallergic properties of fluoroquinolone antibiotics (FQ) are remarkable, the mechanisms involved in these processes are not completely understood. For this reason, it is considered worthwhile to study in detail the photochemical interactions of lomefloxacin (LFX) and its N-acetyl derivative ALFX, two 6,8-dihalogenated fluoroquinolones, with the most abundant protein in human plasma (human serum albumin, HSA) to analyze their covalent binding. Fluorescence measurements and laser flash photolysis experiments performed in this work have revealed that N-acetylation of the LFX piperazinyl moiety produces an important increase of the drug affinity to albumin. Thus, while the association constant (Ka) for the LFX···HSA complex is below 103 M–1, the Ka for the HSA···ALFX complex resulted in ca. 5 × 103 M–1. Interestingly, LFX is mainly located at site I of HSA, while ALFX shows no preference for site I or II. A high reactivity between the aryl cations generated from (A)LFX dehalogenation and Trp and Tyr together with the generation of covalent adducts between the FQ and these amino acids was observed. However, the interactions between the FQ singlet excited state and albumin in FQ···HSA complexes seem to be the key process of FQ covalent binding to albumin. Moreover, our findings have shown a correlation between the photobinding properties of dihalogenated fluoroquinolones to HSA and their FQ···HSA association constants." @default.
- W2326551727 created "2016-06-24" @default.
- W2326551727 creator A5000766188 @default.
- W2326551727 creator A5010802024 @default.
- W2326551727 creator A5082871041 @default.
- W2326551727 date "2014-02-26" @default.
- W2326551727 modified "2023-10-06" @default.
- W2326551727 title "Understanding of the Photoallergic Properties of Fluoroquinolones: Photoreactivity of Lomefloxacin with Amino Acids and Albumin" @default.
- W2326551727 cites W1548941984 @default.
- W2326551727 cites W1942097613 @default.
- W2326551727 cites W1969843356 @default.
- W2326551727 cites W1976072527 @default.
- W2326551727 cites W1976080857 @default.
- W2326551727 cites W1976444245 @default.
- W2326551727 cites W1981306353 @default.
- W2326551727 cites W1988389998 @default.
- W2326551727 cites W1989052893 @default.
- W2326551727 cites W1993273298 @default.
- W2326551727 cites W1993550305 @default.
- W2326551727 cites W1999368780 @default.
- W2326551727 cites W2008807468 @default.
- W2326551727 cites W2012763093 @default.
- W2326551727 cites W2013444669 @default.
- W2326551727 cites W2013572877 @default.
- W2326551727 cites W2015428714 @default.
- W2326551727 cites W2023178402 @default.
- W2326551727 cites W2027368559 @default.
- W2326551727 cites W2028618950 @default.
- W2326551727 cites W2032580699 @default.
- W2326551727 cites W2034136876 @default.
- W2326551727 cites W2039194001 @default.
- W2326551727 cites W2039617001 @default.
- W2326551727 cites W2046153242 @default.
- W2326551727 cites W2050103155 @default.
- W2326551727 cites W2051655155 @default.
- W2326551727 cites W2051849794 @default.
- W2326551727 cites W2056248732 @default.
- W2326551727 cites W2056446567 @default.
- W2326551727 cites W2057951548 @default.
- W2326551727 cites W2064177071 @default.
- W2326551727 cites W2066836879 @default.
- W2326551727 cites W2074272897 @default.
- W2326551727 cites W2076562395 @default.
- W2326551727 cites W2078408747 @default.
- W2326551727 cites W2079490329 @default.
- W2326551727 cites W2080480885 @default.
- W2326551727 cites W2080706408 @default.
- W2326551727 cites W2084280001 @default.
- W2326551727 cites W2084878888 @default.
- W2326551727 cites W2085454968 @default.
- W2326551727 cites W2090181618 @default.
- W2326551727 cites W2090689000 @default.
- W2326551727 cites W2091162401 @default.
- W2326551727 cites W2092346411 @default.
- W2326551727 cites W2132920667 @default.
- W2326551727 cites W2140907764 @default.
- W2326551727 cites W2144664843 @default.
- W2326551727 cites W2147132736 @default.
- W2326551727 cites W2151128886 @default.
- W2326551727 cites W2283415054 @default.
- W2326551727 cites W2316384881 @default.
- W2326551727 cites W2318521207 @default.
- W2326551727 cites W2342879507 @default.
- W2326551727 cites W2952171982 @default.
- W2326551727 cites W2004484907 @default.
- W2326551727 doi "https://doi.org/10.1021/tx400377s" @default.
- W2326551727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24528107" @default.
- W2326551727 hasPublicationYear "2014" @default.
- W2326551727 type Work @default.
- W2326551727 sameAs 2326551727 @default.
- W2326551727 citedByCount "12" @default.
- W2326551727 countsByYear W23265517272015 @default.
- W2326551727 countsByYear W23265517272016 @default.
- W2326551727 countsByYear W23265517272017 @default.
- W2326551727 countsByYear W23265517272018 @default.
- W2326551727 countsByYear W23265517272019 @default.
- W2326551727 countsByYear W23265517272020 @default.
- W2326551727 countsByYear W23265517272021 @default.
- W2326551727 countsByYear W23265517272023 @default.
- W2326551727 crossrefType "journal-article" @default.
- W2326551727 hasAuthorship W2326551727A5000766188 @default.
- W2326551727 hasAuthorship W2326551727A5010802024 @default.
- W2326551727 hasAuthorship W2326551727A5082871041 @default.
- W2326551727 hasConcept C108204754 @default.
- W2326551727 hasConcept C121332964 @default.
- W2326551727 hasConcept C13472781 @default.
- W2326551727 hasConcept C148898269 @default.
- W2326551727 hasConcept C178790620 @default.
- W2326551727 hasConcept C180577832 @default.
- W2326551727 hasConcept C185592680 @default.
- W2326551727 hasConcept C21951064 @default.
- W2326551727 hasConcept C2776125364 @default.
- W2326551727 hasConcept C2776568683 @default.
- W2326551727 hasConcept C2778049240 @default.
- W2326551727 hasConcept C2778512257 @default.
- W2326551727 hasConcept C2778597219 @default.
- W2326551727 hasConcept C2778923102 @default.
- W2326551727 hasConcept C2780263894 @default.