Matches in SemOpenAlex for { <https://semopenalex.org/work/W2326576211> ?p ?o ?g. }
- W2326576211 abstract "Focal segmental glomerulosclerosis (FSGS) is a renal pathology finding that represents a constellation of rare kidney diseases, which manifest as proteinuria, edema nephrotic syndrome, hypertension, and increased risk for kidney failure. Therapeutic options for FSGS are reviewed displaying the expected efficacy from 25 to 69% depending on specific therapy, patient characteristics, cost, and common side effects. This variability in treatment response is likely caused, in part, by the heterogeneity in the etiology and active molecular mechanisms of FSGS. Clinical trials in FSGS have been scant in number and slow to recruit, which may stem, in part, from reliance on classic clinical trial design paradigms. Traditional clinical trial designs based on the learn and confirm paradigm may not be appropriate for rare diseases, such as FSGS. Future drug development and testing will require novel approaches to trial designs that have the capacity to enrich study populations and adapt the trial in a planned way to gain efficiencies in trial completion timelines. A clinical trial simulation is provided that compares a classical and more modern design to determine the maximum tolerated dose in FSGS." @default.
- W2326576211 created "2016-06-24" @default.
- W2326576211 creator A5023311441 @default.
- W2326576211 creator A5040962057 @default.
- W2326576211 creator A5054993212 @default.
- W2326576211 creator A5064564783 @default.
- W2326576211 creator A5087878848 @default.
- W2326576211 creator A5089653898 @default.
- W2326576211 date "2016-03-23" @default.
- W2326576211 modified "2023-10-07" @default.
- W2326576211 title "Changing the Paradigm for the Treatment and Development of New Therapies for FSGS" @default.
- W2326576211 cites W1578533615 @default.
- W2326576211 cites W1965248635 @default.
- W2326576211 cites W1965482229 @default.
- W2326576211 cites W1966768512 @default.
- W2326576211 cites W1970563897 @default.
- W2326576211 cites W1985483877 @default.
- W2326576211 cites W1986502618 @default.
- W2326576211 cites W1988778209 @default.
- W2326576211 cites W1989659831 @default.
- W2326576211 cites W1994023219 @default.
- W2326576211 cites W2001427453 @default.
- W2326576211 cites W2011983555 @default.
- W2326576211 cites W2013493069 @default.
- W2326576211 cites W2026703386 @default.
- W2326576211 cites W2030295061 @default.
- W2326576211 cites W2035802792 @default.
- W2326576211 cites W2037773537 @default.
- W2326576211 cites W2044390029 @default.
- W2326576211 cites W2044439361 @default.
- W2326576211 cites W2051341588 @default.
- W2326576211 cites W2054383376 @default.
- W2326576211 cites W2055198260 @default.
- W2326576211 cites W2064948485 @default.
- W2326576211 cites W2065179459 @default.
- W2326576211 cites W2067106492 @default.
- W2326576211 cites W2069607843 @default.
- W2326576211 cites W2076108528 @default.
- W2326576211 cites W2082770695 @default.
- W2326576211 cites W2088238660 @default.
- W2326576211 cites W2090054860 @default.
- W2326576211 cites W2091209566 @default.
- W2326576211 cites W2095763846 @default.
- W2326576211 cites W2098980231 @default.
- W2326576211 cites W2103044501 @default.
- W2326576211 cites W2107836148 @default.
- W2326576211 cites W2111992695 @default.
- W2326576211 cites W2116622513 @default.
- W2326576211 cites W2117173606 @default.
- W2326576211 cites W2118120805 @default.
- W2326576211 cites W2125300671 @default.
- W2326576211 cites W2131980568 @default.
- W2326576211 cites W2132254057 @default.
- W2326576211 cites W2132265655 @default.
- W2326576211 cites W2137096226 @default.
- W2326576211 cites W2151438241 @default.
- W2326576211 cites W2155316639 @default.
- W2326576211 cites W2157220116 @default.
- W2326576211 cites W2211315092 @default.
- W2326576211 cites W2300541174 @default.
- W2326576211 cites W2512907691 @default.
- W2326576211 cites W2594454279 @default.
- W2326576211 cites W4230575479 @default.
- W2326576211 cites W4234951103 @default.
- W2326576211 cites W4254340645 @default.
- W2326576211 cites W68380001 @default.
- W2326576211 doi "https://doi.org/10.3389/fped.2016.00025" @default.
- W2326576211 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4803734" @default.
- W2326576211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27047908" @default.
- W2326576211 hasPublicationYear "2016" @default.
- W2326576211 type Work @default.
- W2326576211 sameAs 2326576211 @default.
- W2326576211 citedByCount "8" @default.
- W2326576211 countsByYear W23265762112017 @default.
- W2326576211 countsByYear W23265762112018 @default.
- W2326576211 countsByYear W23265762112020 @default.
- W2326576211 countsByYear W23265762112022 @default.
- W2326576211 countsByYear W23265762112023 @default.
- W2326576211 crossrefType "journal-article" @default.
- W2326576211 hasAuthorship W2326576211A5023311441 @default.
- W2326576211 hasAuthorship W2326576211A5040962057 @default.
- W2326576211 hasAuthorship W2326576211A5054993212 @default.
- W2326576211 hasAuthorship W2326576211A5064564783 @default.
- W2326576211 hasAuthorship W2326576211A5087878848 @default.
- W2326576211 hasAuthorship W2326576211A5089653898 @default.
- W2326576211 hasBestOaLocation W23265762111 @default.
- W2326576211 hasConcept C126322002 @default.
- W2326576211 hasConcept C177713679 @default.
- W2326576211 hasConcept C2778415529 @default.
- W2326576211 hasConcept C2778930706 @default.
- W2326576211 hasConcept C2779561371 @default.
- W2326576211 hasConcept C2780091579 @default.
- W2326576211 hasConcept C535046627 @default.
- W2326576211 hasConcept C60644358 @default.
- W2326576211 hasConcept C71924100 @default.
- W2326576211 hasConcept C86803240 @default.
- W2326576211 hasConceptScore W2326576211C126322002 @default.
- W2326576211 hasConceptScore W2326576211C177713679 @default.
- W2326576211 hasConceptScore W2326576211C2778415529 @default.
- W2326576211 hasConceptScore W2326576211C2778930706 @default.