Matches in SemOpenAlex for { <https://semopenalex.org/work/W2326607258> ?p ?o ?g. }
- W2326607258 endingPage "1180" @default.
- W2326607258 startingPage "1174" @default.
- W2326607258 abstract "Objective: The objective of this study was to determine the contribution of lymphatic tissue to heterotopic ossification (HO). Background: HO is the pathologic development of ectopic bone within soft tissues often following severe trauma. Characterization of the tissue niche supporting HO is critical to identifying therapies directed against this condition. Lymphangiogenesis is upregulated during incidents of trauma, thereby coincident with the niche supportive of HO. We hypothesized that lymphatic tissues play a critical role in HO formation. Methods: Mice underwent hindlimb Achilles’ tendon transection and dorsal burn injury (burn/tenotomy) to induce HO. The popliteal and inguinal lymph nodes were excised ipsilateral to the tenotomy site. Flow cytometry and immunostaining were used to quantify and localize lymphoendothelium. MicroCT was used to quantify HO. Results: Enrichment of mature lymphatic tissues was noted 2 weeks after injury at the tendon transection sites when compared with the contralateral, intact tendon based on LYVE1+ tubules (10.9% vs 0.8%, P < 0.05). Excision of the inguinal and popliteal nodes with draining popliteal lymphatic vessel significantly decreased the presence of mature lymphoendothelium 2 weeks after injury (10.9% vs 3.3%, P < 0.05). Bone-cartilage-stromal progenitor cells (CD105+/AlphaV+/Tie2-/CD45-/CD90-/BP1-) were also significantly decreased after lymph node excision (10.2% vs 0.5%, P < 0.05). A significant decrease was noted in the volume of de novo HO present within the soft tissues (0.12 mm3 vs 0.02 mm3). Conclusion: These findings suggest that lymphatic vessels are intimately linked with the de novo formation bone within soft tissues following trauma, and their presence may facilitate bone formation." @default.
- W2326607258 created "2016-06-24" @default.
- W2326607258 creator A5003998623 @default.
- W2326607258 creator A5004145046 @default.
- W2326607258 creator A5005998747 @default.
- W2326607258 creator A5028230798 @default.
- W2326607258 creator A5041311658 @default.
- W2326607258 creator A5061980421 @default.
- W2326607258 creator A5062454721 @default.
- W2326607258 creator A5073831619 @default.
- W2326607258 creator A5076096997 @default.
- W2326607258 creator A5081956660 @default.
- W2326607258 creator A5085384148 @default.
- W2326607258 date "2016-12-01" @default.
- W2326607258 modified "2023-10-14" @default.
- W2326607258 title "Lymphatic Contribution to the Cellular Niche in Heterotopic Ossification" @default.
- W2326607258 cites W1966007699 @default.
- W2326607258 cites W1967260218 @default.
- W2326607258 cites W1972228155 @default.
- W2326607258 cites W1991386745 @default.
- W2326607258 cites W1991387403 @default.
- W2326607258 cites W1992532574 @default.
- W2326607258 cites W1997897024 @default.
- W2326607258 cites W2001561950 @default.
- W2326607258 cites W2009680944 @default.
- W2326607258 cites W200979454 @default.
- W2326607258 cites W2011196087 @default.
- W2326607258 cites W2020545615 @default.
- W2326607258 cites W2021124413 @default.
- W2326607258 cites W2029557891 @default.
- W2326607258 cites W2030349987 @default.
- W2326607258 cites W2032085255 @default.
- W2326607258 cites W2033388509 @default.
- W2326607258 cites W2050032040 @default.
- W2326607258 cites W2060238312 @default.
- W2326607258 cites W2065705414 @default.
- W2326607258 cites W2071439944 @default.
- W2326607258 cites W2077504823 @default.
- W2326607258 cites W2078691010 @default.
- W2326607258 cites W2082047692 @default.
- W2326607258 cites W2082548515 @default.
- W2326607258 cites W2083447892 @default.
- W2326607258 cites W2089027043 @default.
- W2326607258 cites W2108485405 @default.
- W2326607258 cites W2128627731 @default.
- W2326607258 cites W2139561575 @default.
- W2326607258 cites W2145304853 @default.
- W2326607258 cites W2313850888 @default.
- W2326607258 cites W2314650874 @default.
- W2326607258 cites W2354972079 @default.
- W2326607258 doi "https://doi.org/10.1097/sla.0000000000001619" @default.
- W2326607258 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4947025" @default.
- W2326607258 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26779981" @default.
- W2326607258 hasPublicationYear "2016" @default.
- W2326607258 type Work @default.
- W2326607258 sameAs 2326607258 @default.
- W2326607258 citedByCount "7" @default.
- W2326607258 countsByYear W23266072582017 @default.
- W2326607258 countsByYear W23266072582018 @default.
- W2326607258 countsByYear W23266072582019 @default.
- W2326607258 countsByYear W23266072582020 @default.
- W2326607258 countsByYear W23266072582022 @default.
- W2326607258 crossrefType "journal-article" @default.
- W2326607258 hasAuthorship W2326607258A5003998623 @default.
- W2326607258 hasAuthorship W2326607258A5004145046 @default.
- W2326607258 hasAuthorship W2326607258A5005998747 @default.
- W2326607258 hasAuthorship W2326607258A5028230798 @default.
- W2326607258 hasAuthorship W2326607258A5041311658 @default.
- W2326607258 hasAuthorship W2326607258A5061980421 @default.
- W2326607258 hasAuthorship W2326607258A5062454721 @default.
- W2326607258 hasAuthorship W2326607258A5073831619 @default.
- W2326607258 hasAuthorship W2326607258A5076096997 @default.
- W2326607258 hasAuthorship W2326607258A5081956660 @default.
- W2326607258 hasAuthorship W2326607258A5085384148 @default.
- W2326607258 hasBestOaLocation W23266072582 @default.
- W2326607258 hasConcept C105702510 @default.
- W2326607258 hasConcept C121608353 @default.
- W2326607258 hasConcept C126322002 @default.
- W2326607258 hasConcept C136948725 @default.
- W2326607258 hasConcept C142724271 @default.
- W2326607258 hasConcept C181152851 @default.
- W2326607258 hasConcept C2776470705 @default.
- W2326607258 hasConcept C2776636583 @default.
- W2326607258 hasConcept C2777593132 @default.
- W2326607258 hasConcept C2779013556 @default.
- W2326607258 hasConcept C2779720271 @default.
- W2326607258 hasConcept C2780105995 @default.
- W2326607258 hasConcept C2780650075 @default.
- W2326607258 hasConcept C2780984734 @default.
- W2326607258 hasConcept C51279973 @default.
- W2326607258 hasConcept C71924100 @default.
- W2326607258 hasConceptScore W2326607258C105702510 @default.
- W2326607258 hasConceptScore W2326607258C121608353 @default.
- W2326607258 hasConceptScore W2326607258C126322002 @default.
- W2326607258 hasConceptScore W2326607258C136948725 @default.
- W2326607258 hasConceptScore W2326607258C142724271 @default.
- W2326607258 hasConceptScore W2326607258C181152851 @default.
- W2326607258 hasConceptScore W2326607258C2776470705 @default.