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- W2326626972 abstract "Functionally reversing the β-oxidation cycle represents an efficient and versatile strategy for synthesis of a wide variety of fuels and chemicals. However, due to the compartmentalization of cellular metabolisms, reversing the β-oxidation cycle in eukaryotic systems remains elusive. Here, we report the first successful reversal of the β-oxidation cycle in Saccharomyces cerevisiae, an important cell factory for large-scale production of fuels and chemicals. After extensive gene cloning and enzyme activity assays, a reversed β-oxidation pathway was functionally constructed in the yeast cytosol, which led to the synthesis of n-butanol, medium-chain fatty acids (MCFAs), and medium-chain fatty acid ethyl esters (MCFAEEs). The resultant recombinant strain provides a new broadly applicable platform for synthesis of fuels and chemicals in S. cerevisiae." @default.
- W2326626972 created "2016-06-24" @default.
- W2326626972 creator A5014465828 @default.
- W2326626972 creator A5052493543 @default.
- W2326626972 date "2014-07-02" @default.
- W2326626972 modified "2023-10-01" @default.
- W2326626972 title "Reversal of the β-Oxidation Cycle in <i>Saccharomyces cerevisiae</i> for Production of Fuels and Chemicals" @default.
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- W2326626972 doi "https://doi.org/10.1021/sb500243c" @default.
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