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- W2326655258 abstract "Synovial sarcomas arising in unexpected locations may lead to diagnostic challenges. In this report, we describe 3 cases of synovial sarcoma that manifested clinically as primary pericardial lesions. All 3 cases occurred in men in their fourth decade. Fever, cough, chest pain, and chest distress were the most common symptoms. Histologically, 2 of the tumors were spindle cell monophasic, and 1 tumor was biphasic. By immunohistochemical studies, the tumor cells were positive for cytokeratins and epithelial membrane antigen. In addition, the tumor cells displayed focal immunoreactivity for calretinin, cytokeratin 5/6, and HBME-1, resulting in the initial interpretations of malignant mesotheliomas. None of the 3 cases were diagnosed correctly until subsequent molecular cytogenetic assays demonstrated the presence of SYT gene rearrangements. As there are overlapping morphologic features between pericardial synovial sarcoma and mesothelioma, molecular analysis is essential for differential diagnoses." @default.
- W2326655258 created "2016-06-24" @default.
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- W2326655258 date "2012-01-01" @default.
- W2326655258 modified "2023-10-11" @default.
- W2326655258 title "Pericardial Synovial Sarcoma, a Potential for Misdiagnosis" @default.
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- W2326655258 doi "https://doi.org/10.1309/ajcp34zvflautmgl" @default.
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