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- W2326676827 abstract "This paper deals with the antithrombin activities of synthetic acidic polysaccharides. These synthetic acidic polysaccharides have different viscosities and numbers of sulfates. Correlations between the anticoagulant activities and the viscocities and numbers of sulfates were investigated by means of the heparin cofactor method.The following results were obtained:1) The antithrombin activity of acidic polysaccharides alone showed a positive correlation between antithrombin activity and viscosity.2) The cooperative actions of acidic polysaccharides which have high viscosities with AT III did not show any increase in the antithrombin activities of AT III. But the cooperative actions of acidic polysaccharides which have low viscosities showed an increase in the antithrombin activities of AT III.3) There were no absolute correlations between the antithrombin activities of acidic polysaccharides alone and the numbers of sulfates.4) Acidic polysaccharides with a 10% to 20% sulfate content were necessary to increase the antithrombin activities of AT III." @default.
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- W2326676827 date "1980-01-01" @default.
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- W2326676827 title "Antithrombin activities of acidic polysaccharides" @default.
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- W2326676827 doi "https://doi.org/10.2491/jjsth1970.11.211" @default.
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