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- W2326691625 abstract "Von Willebrand Factor (VWF) expression is restricted to endothelial cells and megakaryocytes. VWF mediates recruitment of platelets to the subendothelium at the site of injury. Additionally, VWF has been proposed to contribute to tumor development and metastasis. Increased VWF is shown in the sera of various tumor patients, and VWF has been detected in a tumor cell line of non-endothelial origin, namely osteosarcoma Saso2 cell line. We and others have identified a number of transacting factors that participate in cell type and organ-specific regulation of VWF transcription. We have also recently reported that VWF transcription is upregulated in response to hypoxia and that transcription factor YY1 participate in this process. We have now extended our analyses of VWF expression to tumor cells and investigated de novo expression as well as hypoxia induction of VWF in glioma and osteosarcoma cell lines." @default.
- W2326691625 created "2016-06-24" @default.
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- W2326691625 date "2013-10-01" @default.
- W2326691625 modified "2023-10-16" @default.
- W2326691625 title "Expression of VWF Endothelial Specific Gene in Some Cancer Cells" @default.
- W2326691625 doi "https://doi.org/10.1016/j.cjca.2013.07.253" @default.
- W2326691625 hasPublicationYear "2013" @default.
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