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• W2326696815 endingPage "4349" @default.
• W2326696815 startingPage "4335" @default.
• W2326696815 abstract "Exposition of unilamellar vesicles to attractive surfaces is a frequently used way to create supported lipid bilayers. Although this approach is known to produce continuous supported bilayer coatings, the mechanism of their formation and its dependence on factors like surface interaction and roughness or membrane tension as well as the interplay between neighboring vesicles or the involvement of preadsorbed bilayer patches are not well understood. Using dissipative particle dynamics simulations, we assess different mechanisms of vesicle spreading on attractive surfaces, placing special emphasis on the orientation of the resulting bilayer. Making use of the universality of collective phenomena in lipid membranes, we employed a solvent-free coarse-grained model, enabling us to cover the relatively large system sizes and time scales required. Our results indicate that one can control the mechanism of vesicle spreading by tuning the strength and range of the interactions with the substrate as well as the surface’s roughness, resulting in a switch from a predominant inside-up to an outside-up orientation of the created supported bilayer." @default.
• W2326696815 created "2016-06-24" @default.
• W2326696815 creator A5012585792 @default.
• W2326696815 creator A5039236603 @default.
• W2326696815 date "2013-03-21" @default.
• W2326696815 modified "2023-10-16" @default.
• W2326696815 title "Mechanisms of Vesicle Spreading on Surfaces: Coarse-Grained Simulations" @default.
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• W2326696815 doi "https://doi.org/10.1021/la400119e" @default.
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• W2326696815 hasPublicationYear "2013" @default.
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