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• W2326698730 startingPage "1" @default.
• W2326698730 abstract "Cell death is a common and important feature of animal development, and cell death defects underlie many human disease states. The nematode Caenorhabditis elegans has proven fertile ground for uncovering molecular and cellular processes controlling programmed cell death. A core pathway consisting of the conserved proteins EGL-1/BH3-only, CED-9/BCL2, CED-4/APAF1, and CED-3/caspase promotes most cell death in the nematode, and a conserved set of proteins ensures the engulfment and degradation of dying cells. Multiple regulatory pathways control cell death onset in C. elegans, and many reveal similarities with tumor formation pathways in mammals, supporting the idea that cell death plays key roles in malignant progression. Nonetheless, a number of observations suggest that our understanding of developmental cell death in C. elegans is incomplete. The interaction between dying and engulfing cells seems to be more complex than originally appreciated, and it appears that key aspects of cell death initiation are not fully understood. It has also become apparent that the conserved apoptotic pathway is dispensable for the demise of the C. elegans linker cell, leading to the discovery of a previously unexplored gene program promoting cell death. Here, we review studies that formed the foundation of cell death research in C. elegans and describe new observations that expand, and in some cases remodel, this edifice. We raise the possibility that, in some cells, more than one death program may be needed to ensure cell death fidelity." @default.
• W2326698730 created "2016-06-24" @default.
• W2326698730 creator A5009110539 @default.
• W2326698730 creator A5044535425 @default.
• W2326698730 date "2015-01-01" @default.
• W2326698730 modified "2023-10-14" @default.
• W2326698730 title "Cell Death in C. elegans Development" @default.
• W2326698730 cites W143343688 @default.
• W2326698730 cites W1488265246 @default.
• W2326698730 cites W1501301649 @default.
• W2326698730 cites W1523693806 @default.
• W2326698730 cites W1533988685 @default.
• W2326698730 cites W1536961425 @default.
• W2326698730 cites W1583459471 @default.
• W2326698730 cites W1612820086 @default.
• W2326698730 cites W1624001120 @default.
• W2326698730 cites W1845459216 @default.
• W2326698730 cites W1891611787 @default.
• W2326698730 cites W1910292850 @default.
• W2326698730 cites W1911240597 @default.
• W2326698730 cites W1922553141 @default.
• W2326698730 cites W1924646174 @default.
• W2326698730 cites W1948927501 @default.
• W2326698730 cites W1964679826 @default.
• W2326698730 cites W1968505830 @default.
• W2326698730 cites W1969042688 @default.
• W2326698730 cites W1969331809 @default.
• W2326698730 cites W1974047098 @default.
• W2326698730 cites W1974646500 @default.
• W2326698730 cites W1976133790 @default.
• W2326698730 cites W1976290892 @default.
• W2326698730 cites W1976312800 @default.
• W2326698730 cites W1983477032 @default.
• W2326698730 cites W1984944970 @default.
• W2326698730 cites W1985349184 @default.
• W2326698730 cites W1985426749 @default.
• W2326698730 cites W1986006829 @default.
• W2326698730 cites W1989026904 @default.
• W2326698730 cites W1989442441 @default.
• W2326698730 cites W1989952069 @default.
• W2326698730 cites W1990832657 @default.
• W2326698730 cites W1991159765 @default.
• W2326698730 cites W1991880183 @default.
• W2326698730 cites W1995653570 @default.
• W2326698730 cites W1995891719 @default.
• W2326698730 cites W1996234796 @default.
• W2326698730 cites W1996271683 @default.
• W2326698730 cites W1996724986 @default.
• W2326698730 cites W1997831655 @default.
• W2326698730 cites W1998116375 @default.
• W2326698730 cites W1999582764 @default.
• W2326698730 cites W2000193215 @default.
• W2326698730 cites W2002329941 @default.
• W2326698730 cites W2006818360 @default.
• W2326698730 cites W2007863176 @default.
• W2326698730 cites W2008348103 @default.
• W2326698730 cites W2009876130 @default.
• W2326698730 cites W2013016555 @default.
• W2326698730 cites W2013159980 @default.
• W2326698730 cites W2023462381 @default.
• W2326698730 cites W2024795929 @default.
• W2326698730 cites W2027638828 @default.
• W2326698730 cites W2030546970 @default.
• W2326698730 cites W2031607201 @default.
• W2326698730 cites W2031840568 @default.
• W2326698730 cites W2032357445 @default.
• W2326698730 cites W2032446466 @default.
• W2326698730 cites W2034591877 @default.
• W2326698730 cites W2038055601 @default.
• W2326698730 cites W2039568484 @default.
• W2326698730 cites W2042141743 @default.
• W2326698730 cites W2045287862 @default.
• W2326698730 cites W2046845002 @default.
• W2326698730 cites W2047107948 @default.
• W2326698730 cites W2047293798 @default.
• W2326698730 cites W2048750043 @default.
• W2326698730 cites W2051658957 @default.
• W2326698730 cites W2053976302 @default.
• W2326698730 cites W2054918036 @default.
• W2326698730 cites W2055304598 @default.
• W2326698730 cites W2057197224 @default.
• W2326698730 cites W2059666350 @default.
• W2326698730 cites W2060483038 @default.
• W2326698730 cites W2060814715 @default.
• W2326698730 cites W2060876398 @default.
• W2326698730 cites W2062807784 @default.
• W2326698730 cites W2065482981 @default.
• W2326698730 cites W2066171290 @default.
• W2326698730 cites W2066982978 @default.
• W2326698730 cites W2067751406 @default.
• W2326698730 cites W2068240610 @default.
• W2326698730 cites W2070461863 @default.
• W2326698730 cites W2070920868 @default.
• W2326698730 cites W2071481601 @default.
• W2326698730 cites W2072273093 @default.
• W2326698730 cites W2072692243 @default.
• W2326698730 cites W2075536470 @default.
• W2326698730 cites W2076534314 @default.

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