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- W2326702979 abstract "Previous reports(,) concerning the disappearance of a tracer dose of radioactive iron from the plasma implied a single plasma iron pool with no significant return of radioiron to the plasma during the experimental period of one to 2 hours. Assuming instantaneous mixing following the injection of ferric 59-beta-1 globulinate, as well as a constant relative disappearance rate, the theoretical data could be represented by a single exponential function, i.e., a straight line on semi-log paper. Such a first approximation fitted the experimental data well because of the large errors involved in electroplating() and the relatively insensitive counting technics employed(). Two considerations prompted reevaluation of the above concepts. Firstly, utilizing improved counting technics it was noted that the experimental data were no longer approximated by a straight line when plotted on semilog paper. Re-examination of some of the published data in earlier reports reveals similar findings(,). Secondly, the application of the previous approach to cases of polycythemia vera led to excessively high hemoglobin renewal rates and consequent shortened red cell survival times(). These findings were not in accord with data obtained by other methods(), nor with present basic concepts of the patho-physiology of this disorder(). It will be demonstrated that the experimental data can be more closely approximated by the sum of 2 exponential functions, thus requiring a more complex system than the one-pool model implied by the single exponential function. Fig. 1a represents experimental data from a case of polycythemia vera plotted on a semilog scale, for the first hour of Fe59 disappearance from the plasma." @default.
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- W2326702979 date "1954-11-01" @default.
- W2326702979 modified "2023-09-27" @default.
- W2326702979 title "Pool Systems in Iron Metabolism; with Special Reference to Polycythemia Vera." @default.
- W2326702979 doi "https://doi.org/10.3181/00379727-87-21421" @default.
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