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- W2326707983 abstract "Abstract Proteins are considered to be the key players in structure, function, and metabolic regulation of our bodies. The mechanisms used in conventional therapies often rely on inhibition of proteins with small molecules, but another promising method to treat disease is by targeting the corresponding mRNAs. In 1998, Craig Mellow and Andrew Fire discovered dsRNA-mediated gene silencing via RNA interference or RNAi. This discovery introduced almost unlimited possibilities for new gene silencing methods, thus opening new doors to clinical medicine. RNAi is a biological process that inhibits gene expression by targeting the mRNA. RNAi-based therapeutics have several potential advantages (i) a priori ability to target any gene, (ii) relatively simple design process, (iii) sitespecificity, (iv) potency, and (v) a potentially safe and selective knockdown of the targeted cells. However, the problem lies within the formulation and delivery of RNAi therapeutics including rapid excretion, instability in the bloodstream, poor cellular uptake, and inefficient intracellular release. In an attempt to solve these issues, different types of RNAi therapeutic delivery strategies including multifunctional RNA nanoparticles are being developed. In this mini-review, we will briefly describe some of the current approaches." @default.
- W2326707983 created "2016-06-24" @default.
- W2326707983 creator A5010562576 @default.
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- W2326707983 date "2015-01-27" @default.
- W2326707983 modified "2023-10-09" @default.
- W2326707983 title "Triggering RNAi with multifunctional RNA nanoparticles and their delivery" @default.
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- W2326707983 doi "https://doi.org/10.1515/rnan-2015-0001" @default.
- W2326707983 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8315566" @default.
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