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- W2326709700 abstract "It is a plain fact that we are doing research in a need-to-cure-world. When our understanding of a disease pathology is a work in progress, it is often wise to focus on specific aspects of the disorder, gain an understanding of its components that will be assembled in a conceptual framework, and proceed to a therapy based approach [1]. Thus, before envisioning a cure for addiction, let us critically analyze whether our attempts to understand this exceedingly complex phenomenon using animal model systems atleast nearly reflect the human condition. To study a given scientific hypothesis, choices of model/model organisms are essential and options can be many. The model setting is complex. Frequently, responses connected to drug/addiction do not occur equally between humans (intraspecies variability) and variation in such responses between species can be even more diverse (interspecies variability). Additionally, when addressing “addiction” we have a multifactorial setting of intricate, imperfectly understood human behavior mechanisms e.g. craving, executive control that ideally would be mimicked in animal models. Realistically, the latter may only be possible in part. Thus, there exists a plethora of real and potential model systems and experimental approaches attempting to essentially address the same questions. The following thoughts (both scientific and opinions) are largely, inspired by Dr. Andrey Ryabinin’s talk entitled “New hopes from evolutionary approaches to animal models of alcoholism and addiction” in the First International Conference and Exhibition on Addiction Research & Therapy in Las Vegas, USA (Aug 20-22, 2012)." @default.
- W2326709700 created "2016-06-24" @default.
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- W2326709700 date "2014-01-01" @default.
- W2326709700 modified "2023-09-26" @default.
- W2326709700 title "Where to from here?" @default.
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- W2326709700 doi "https://doi.org/10.4172/2155-6105.1000e120" @default.
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