FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2326735692> ?p ?o ?g. }

• W2326735692 endingPage "584" @default.
• W2326735692 startingPage "573" @default.
• W2326735692 abstract "Epithelial organs are made of a well-polarized monolayer of epithelial cells, and their morphology is maintained strictly for their proper functioning. The roles of lipids are not only to generate the membrane, but also to provide the specific domains for signal transduction, or to transmit signals as second messengers. By using a liquid chromatography-electrospray ionization mass spectrometry (LC-MS)/MS method, we here analyzed sphingolipids in MDCK cysts under various conditions. Our result showed that, compared to the three-dimensional cyst, the two-dimensional MDCK sheet is relatively enriched in sphingolipids. During cystogenesis, the contents of sphingomyelin (SM) and lactocylceramide (LacCer)—but, none those of ceramide, hexocylceramide, or GM3—are altered depending on their acyl chains. While the total SM is decreased more efficiently by SMS-1 knockdown than by SMS-2 knockdown, depletion of SMS-2, but not SMS-1, inhibits cyst growth. Finally upon the switching on of activated K-Ras expression which induces luminal cell filling, ceramide and LacCer are increased. Our parallel examinations of the microarray data for mRNA of sphingolipid metabolic enzymes failed to fully explain the remodelling of the sphingolipids of MDCK cysts. However, these results should be useful to investigate the cell-type- and structure-specific lipid metabolism." @default.
• W2326735692 created "2016-06-24" @default.
• W2326735692 creator A5006996165 @default.
• W2326735692 creator A5032069454 @default.
• W2326735692 creator A5049630622 @default.
• W2326735692 creator A5091657418 @default.
• W2326735692 date "2016-01-18" @default.
• W2326735692 modified "2023-09-27" @default.
• W2326735692 title "Comparative lipid analysis in the normal and cancerous organoids of MDCK cells" @default.
• W2326735692 cites W1964333640 @default.
• W2326735692 cites W1965442929 @default.
• W2326735692 cites W1965813899 @default.
• W2326735692 cites W1966452335 @default.
• W2326735692 cites W1972204116 @default.
• W2326735692 cites W1972880960 @default.
• W2326735692 cites W1985199555 @default.
• W2326735692 cites W1993261987 @default.
• W2326735692 cites W1995194932 @default.
• W2326735692 cites W2002340855 @default.
• W2326735692 cites W2011078603 @default.
• W2326735692 cites W2014552171 @default.
• W2326735692 cites W2020367862 @default.
• W2326735692 cites W2021882008 @default.
• W2326735692 cites W2030426329 @default.
• W2326735692 cites W2031401392 @default.
• W2326735692 cites W2037947363 @default.
• W2326735692 cites W2055470772 @default.
• W2326735692 cites W2062835218 @default.
• W2326735692 cites W2082827406 @default.
• W2326735692 cites W2085955396 @default.
• W2326735692 cites W2090535508 @default.
• W2326735692 cites W2094101252 @default.
• W2326735692 cites W2095718486 @default.
• W2326735692 cites W2097881089 @default.
• W2326735692 cites W2099052265 @default.
• W2326735692 cites W2111724662 @default.
• W2326735692 cites W2116903951 @default.
• W2326735692 cites W2120579879 @default.
• W2326735692 cites W2120739582 @default.
• W2326735692 cites W2121318814 @default.
• W2326735692 cites W2135028611 @default.
• W2326735692 cites W2136675411 @default.
• W2326735692 cites W2143739573 @default.
• W2326735692 doi "https://doi.org/10.1093/jb/mvw001" @default.
• W2326735692 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4892391" @default.
• W2326735692 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26783265" @default.
• W2326735692 hasPublicationYear "2016" @default.
• W2326735692 type Work @default.
• W2326735692 sameAs 2326735692 @default.
• W2326735692 citedByCount "6" @default.
• W2326735692 countsByYear W23267356922017 @default.
• W2326735692 countsByYear W23267356922018 @default.
• W2326735692 countsByYear W23267356922019 @default.
• W2326735692 countsByYear W23267356922020 @default.
• W2326735692 countsByYear W23267356922021 @default.
• W2326735692 countsByYear W23267356922022 @default.
• W2326735692 crossrefType "journal-article" @default.
• W2326735692 hasAuthorship W2326735692A5006996165 @default.
• W2326735692 hasAuthorship W2326735692A5032069454 @default.
• W2326735692 hasAuthorship W2326735692A5049630622 @default.
• W2326735692 hasAuthorship W2326735692A5091657418 @default.
• W2326735692 hasBestOaLocation W23267356921 @default.
• W2326735692 hasConcept C104317684 @default.
• W2326735692 hasConcept C163235415 @default.
• W2326735692 hasConcept C173396325 @default.
• W2326735692 hasConcept C185592680 @default.
• W2326735692 hasConcept C190283241 @default.
• W2326735692 hasConcept C2776931407 @default.
• W2326735692 hasConcept C2777851122 @default.
• W2326735692 hasConcept C31695470 @default.
• W2326735692 hasConcept C41625074 @default.
• W2326735692 hasConcept C55493867 @default.
• W2326735692 hasConcept C58017582 @default.
• W2326735692 hasConcept C61322309 @default.
• W2326735692 hasConcept C61705674 @default.
• W2326735692 hasConcept C62478195 @default.
• W2326735692 hasConcept C86803240 @default.
• W2326735692 hasConcept C95444343 @default.
• W2326735692 hasConceptScore W2326735692C104317684 @default.
• W2326735692 hasConceptScore W2326735692C163235415 @default.
• W2326735692 hasConceptScore W2326735692C173396325 @default.
• W2326735692 hasConceptScore W2326735692C185592680 @default.
• W2326735692 hasConceptScore W2326735692C190283241 @default.
• W2326735692 hasConceptScore W2326735692C2776931407 @default.
• W2326735692 hasConceptScore W2326735692C2777851122 @default.
• W2326735692 hasConceptScore W2326735692C31695470 @default.
• W2326735692 hasConceptScore W2326735692C41625074 @default.
• W2326735692 hasConceptScore W2326735692C55493867 @default.
• W2326735692 hasConceptScore W2326735692C58017582 @default.
• W2326735692 hasConceptScore W2326735692C61322309 @default.
• W2326735692 hasConceptScore W2326735692C61705674 @default.
• W2326735692 hasConceptScore W2326735692C62478195 @default.
• W2326735692 hasConceptScore W2326735692C86803240 @default.
• W2326735692 hasConceptScore W2326735692C95444343 @default.
• W2326735692 hasIssue "6" @default.
• W2326735692 hasLocation W23267356921 @default.
• W2326735692 hasLocation W23267356922 @default.
• W2326735692 hasLocation W23267356923 @default.

• next