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- W2326775849 abstract "Triazolo[4,3-a]tetrahydrobenzo(b)thieno[3,2-e]pyrimidine-5(4H)-ones (5a, 5b, 5c, 5d, 5e, 5f, 5g, 5h, 5i, 5j, 5k, 5l, 5m were synthesized and characterized by spectral analysis. All 13 derivatives were evaluated for central nervous system (CNS) depressant and skeletal muscle relaxant activities in Swiss albino mice. All the activities were compared with diazepam as a standard drug at a dose of 5 mg/kg. The most active derivatives 5d, 5e, 5k, and 5l in CNS depressant and skeletal muscle relaxant activities were selected for anticonvulsant activity. The active derivatives were found to protect 100% mice at the dose of 6–11 mg/kg, where as standard diazepam protect the animal at a dose of 2.5 mg/kg." @default.
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- W2326775849 date "2014-05-08" @default.
- W2326775849 modified "2023-09-25" @default.
- W2326775849 title "Synthesis and Pharmacological Evaluation of Novel Triazolo [4, 3-a] tetrahydrobenzo (b) thieno [3, 2-e] pyrimidine-5(4H)-ones" @default.
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- W2326775849 doi "https://doi.org/10.1002/jhet.1989" @default.
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