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- W2326794588 abstract "Quiescent Schwann cells in the distal seg- ment of the permanently transected nerve produced basal lev- els of the major myelin glycoprotein, P0, in the absence of my- elin assembly. Low levels of Po could be detected at 35 days after transection by autoradiographic analysis of radioiodi- nated lectin binding after protein separation by high-resolu- tion sodium dodecyl sulfate pore gradient electrophoresis and by fluorographic analysis after electrophoresis of (3H)fucose- and (3H)mannose-labeled glycoproteins after incorporation into endoneurial slices. Immunoreactivity to Po in the transect- ed nerve could also be demonstrated with antisera against Po as evaluated by direct immune overlay after electrophore- sis. These results indicate that the requirement for continuing signals from appropriate axons to make detectable amounts of myelin-specific proteins and glycolipids is not absolute. Schwann cells, therefore, like oligodendrocytes, can synthesize myelin components in the absence of neuronal influence, al- though information from neuronal elements probably is re- quired for myelin assembly by Schwann cells and for myelin compaction by oligodendrocytes." @default.
- W2326794588 created "2016-06-24" @default.
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- W2326794588 date "2016-01-01" @default.
- W2326794588 modified "2023-09-27" @default.
- W2326794588 title "Schwann cell expression of a major absence of myelin assembly (myelination/biosynthesis of myelin components/oligodendrocytes)" @default.
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- W2326794588 hasPublicationYear "2016" @default.
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