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- W2326820182 abstract "2-(2, 2-Disubstituted ethenyl-and ethyl)-2-imidazoline derivatives (11, 14) were prepared by direct cyclization of active intermediates, 3, 3-disubstituted acrylimidic ethyl esters (9, 10), with ethylenediamine. The stereoisomers, (Z)-and (E)-3-phenyl-3-pyridylacrylic acid esters (6c-e), nitriles (7c-e) and amides (8c-e), as well as (Z)-and (E)-3-phenyl-3-pyridylacrylimidic acid esters (10c-e), and (Z)-and (E)-2-(2-pyridylethenyl)-2-imidazolines (11c-e), were isolated. Their structures are discussed. Compounds 11 and 14 showed potent hypoglycemic activity." @default.
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- W2326820182 date "1980-01-01" @default.
- W2326820182 modified "2023-10-17" @default.
- W2326820182 title "Cyclic guanidines. X. Synthesis of 2-(2,2-disubstituted ethenyl- and ethyl)-2-imidazolines as potent hypoglycemics." @default.
- W2326820182 doi "https://doi.org/10.1248/cpb.28.1394" @default.
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