Matches in SemOpenAlex for { <https://semopenalex.org/work/W2326828822> ?p ?o ?g. }
- W2326828822 abstract "A monolayer of endothelial cells (ECs) lines the lumen of blood vessels and forms a multifunctional trans- ducing organ that regulates cardiovascular homeostasis. Disruption of endothelial integrity, as a result of either angioplasty or stent deployment, may produce a late in-stent restenosis and limit the beneficial outcome of reconstructive vascular surgery. Restoration of endothelial lining requires spreading, migration and proliferation of ECs nearby the lesion site. Intracellular Ca 2+ signalling plays a major regulatory role in stimulating wound healing, however, the mechanism whereby injury increases Ca 2+ levels at the wound edge is still unclear. The analysis of Ca 2+ signals elicited by scraping an endothelial monolayer in vitro suggested the involvement of intracellular Ca 2+ release from InsP3-sensitive stores and Ca 2+ entry through unknown ion channels in the plasma membrane. Recent studies carried out by our group on excised rat aorta highlighted a novel role for connexin hemichannels (ChHcs) in mediating Ca 2+ entry in injured endothelium. This observation sheds new light on the notion that the rate of wound repair is reduced in ECs transfected with dominant negative connexin inhibitors. Understanding the signal transduction pathway leading to EC activation is likely to provide novel targets to design therapeutic applications aiming at restoring endothelial integrity and treating cardiovascular diseases." @default.
- W2326828822 created "2016-06-24" @default.
- W2326828822 creator A5005366121 @default.
- W2326828822 creator A5011506327 @default.
- W2326828822 creator A5021566223 @default.
- W2326828822 creator A5026120374 @default.
- W2326828822 date "2010-11-01" @default.
- W2326828822 modified "2023-10-06" @default.
- W2326828822 title "Ca2+ Signalling in Damaged Endothelium: Do Connexin Hemichannels Aid in Filling the Gap?" @default.
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