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- W2326841683 abstract "The prognosis of acute myeloid leukaemia (AML) is highly dependent on the AML subtype, the presence of cytogenetic (CG) abnormalities and the age and performance status of the patient. The non-random CG abnormalities t(15:17), t(8:21) and inv16 when present at diagnosis are pathognomonic of AML subtypes, indicate the requirement of particular directed therapies and determine a relatively favourable prognosis. Conversely, CG abnormalities such as –5, –7, t(9:22), translocations of the MLL gene, or complex karyotypes confer a poor prognosis with increased refractoriness to induction chemotherapy or early AML relapse. Prognostically midway between these CG groups lies ~50% of AML patients with normal cytogenetic (NCG) AML. NCG AML can be further stratified by detectable mutations that confer either a poor (FLT-3, c-Kit or MLL), or a favourable (NPM-1, CEBPA) prognosis. However, the prognostic interactions between molecular abnormalities and therapeutic decisions are complex, with the favourable impact of NPM-1 and CEPBA only seen in those AML cases without FLT-3 mutations, and c-kit mutations reversing the favourable prognosis of t(8:21) AML, whilst the positive impact of allogeneic transplantation is only seen in patients without a favourable molecular profile. Using these molecular markers a prognostic hierarchy can be constructed to assist in determining AML treatment decisions." @default.
- W2326841683 created "2016-06-24" @default.
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- W2326841683 date "2010-01-01" @default.
- W2326841683 modified "2023-09-27" @default.
- W2326841683 title "Molecular stratification of prognosis and treatment decisions in acute myeloid leukaemia" @default.
- W2326841683 doi "https://doi.org/10.1097/01268031-201042001-00071" @default.
- W2326841683 hasPublicationYear "2010" @default.
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