Matches in SemOpenAlex for { <https://semopenalex.org/work/W2326860060> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2326860060 endingPage "1850" @default.
- W2326860060 startingPage "1837" @default.
- W2326860060 abstract "The activator protein for the degradation of glycolipids GM2 and GA2 by hexosaminidase A was purified some 2 500-fold from normal human kidney. It has a molecular weight of approximately 25 000 is heat-stable up to 60 degrees C, possesses an isoelectric point of pH 4.8 and is digestible by proteases. Enzymic degradation of the lipid substrates in the presence of this activator proceeds optimally at pH 4.2. The mode of action of the activator was also studied: the protein most probably complexes lipid molecules and presents them to the enzyme which otherwise cannot attack the aggregates formed by the lipids in aqueous solution. The hydrolysis of water-soluble synthetic substrates is not affected by the activator protein. The activator is highly specific for hexosaminidase A: hydrolysis of glycolipids GA2 and GM2 by the hexosaminidase B isoenzyme is almost not enhanced by this protein. The isoenzymes' lipid substrate specificity measured in the presence of the activator is entirely different from that obtained with detergents and can satisfactorily account for the lipid storage pattern observed in patients with variant forms of infantile GM2- gangliosidosis." @default.
- W2326860060 created "2016-06-24" @default.
- W2326860060 creator A5007309669 @default.
- W2326860060 creator A5035267875 @default.
- W2326860060 date "1979-01-01" @default.
- W2326860060 modified "2023-09-23" @default.
- W2326860060 title "Purification and Characterization of an Activator Protein for the Degradation of Glycolipids G<sub>M2</sub>and G<sub>A2</sub>by Hexosaminidase A" @default.
- W2326860060 cites W1512575363 @default.
- W2326860060 cites W1519961776 @default.
- W2326860060 cites W1547690027 @default.
- W2326860060 cites W1775749144 @default.
- W2326860060 cites W1965473205 @default.
- W2326860060 cites W1974776807 @default.
- W2326860060 cites W1984560166 @default.
- W2326860060 cites W2173078011 @default.
- W2326860060 cites W2184534762 @default.
- W2326860060 cites W2315083776 @default.
- W2326860060 cites W2419291380 @default.
- W2326860060 cites W2472226023 @default.
- W2326860060 doi "https://doi.org/10.1515/bchm2.1979.360.2.1837" @default.
- W2326860060 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/527942" @default.
- W2326860060 hasPublicationYear "1979" @default.
- W2326860060 type Work @default.
- W2326860060 sameAs 2326860060 @default.
- W2326860060 citedByCount "177" @default.
- W2326860060 countsByYear W23268600602012 @default.
- W2326860060 countsByYear W23268600602015 @default.
- W2326860060 countsByYear W23268600602016 @default.
- W2326860060 countsByYear W23268600602017 @default.
- W2326860060 countsByYear W23268600602018 @default.
- W2326860060 countsByYear W23268600602019 @default.
- W2326860060 countsByYear W23268600602022 @default.
- W2326860060 crossrefType "journal-article" @default.
- W2326860060 hasAuthorship W2326860060A5007309669 @default.
- W2326860060 hasAuthorship W2326860060A5035267875 @default.
- W2326860060 hasConcept C104317684 @default.
- W2326860060 hasConcept C111204789 @default.
- W2326860060 hasConcept C119795356 @default.
- W2326860060 hasConcept C181199279 @default.
- W2326860060 hasConcept C185592680 @default.
- W2326860060 hasConcept C22222904 @default.
- W2326860060 hasConcept C43617362 @default.
- W2326860060 hasConcept C50476208 @default.
- W2326860060 hasConcept C55493867 @default.
- W2326860060 hasConcept C58121356 @default.
- W2326860060 hasConcept C88045685 @default.
- W2326860060 hasConcept C94412978 @default.
- W2326860060 hasConcept C96294017 @default.
- W2326860060 hasConceptScore W2326860060C104317684 @default.
- W2326860060 hasConceptScore W2326860060C111204789 @default.
- W2326860060 hasConceptScore W2326860060C119795356 @default.
- W2326860060 hasConceptScore W2326860060C181199279 @default.
- W2326860060 hasConceptScore W2326860060C185592680 @default.
- W2326860060 hasConceptScore W2326860060C22222904 @default.
- W2326860060 hasConceptScore W2326860060C43617362 @default.
- W2326860060 hasConceptScore W2326860060C50476208 @default.
- W2326860060 hasConceptScore W2326860060C55493867 @default.
- W2326860060 hasConceptScore W2326860060C58121356 @default.
- W2326860060 hasConceptScore W2326860060C88045685 @default.
- W2326860060 hasConceptScore W2326860060C94412978 @default.
- W2326860060 hasConceptScore W2326860060C96294017 @default.
- W2326860060 hasIssue "2" @default.
- W2326860060 hasLocation W23268600601 @default.
- W2326860060 hasLocation W23268600602 @default.
- W2326860060 hasOpenAccess W2326860060 @default.
- W2326860060 hasPrimaryLocation W23268600601 @default.
- W2326860060 hasRelatedWork W1967940207 @default.
- W2326860060 hasRelatedWork W1987880878 @default.
- W2326860060 hasRelatedWork W2022645462 @default.
- W2326860060 hasRelatedWork W2055489316 @default.
- W2326860060 hasRelatedWork W2119581168 @default.
- W2326860060 hasRelatedWork W2326860060 @default.
- W2326860060 hasRelatedWork W294483787 @default.
- W2326860060 hasRelatedWork W4252149215 @default.
- W2326860060 hasRelatedWork W801407824 @default.
- W2326860060 hasRelatedWork W2084674474 @default.
- W2326860060 hasVolume "360" @default.
- W2326860060 isParatext "false" @default.
- W2326860060 isRetracted "false" @default.
- W2326860060 magId "2326860060" @default.
- W2326860060 workType "article" @default.