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- W2326860462 abstract "Summary In Drosophila , Insulin-like peptide 2 (Dilp-2) is expressed by insulin-producing cells in the brain, and is secreted into the hemolymph to activate insulin signaling systemically. Within the brain, however, a more local activation of insulin signaling may be required to couple behavioral and physiological traits to nutritional inputs. We show that a small subset of neurons in the larval brain has high Dilp-2-mediated insulin signaling activity. This local insulin signaling activation is accompanied by selective Dilp-2 uptake and depends on the expression of the Imaginal morphogenesis protein-late 2 (Imp-L2) in the target neurons. We suggest that Imp-L2 acts as a licensing factor for neuronal IIS activation through Dilp-2 to further increase the precision of insulin activity in the brain." @default.
- W2326860462 created "2016-06-24" @default.
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- W2326860462 date "2013-07-15" @default.
- W2326860462 modified "2023-09-27" @default.
- W2326860462 title "The IGFBP7 homolog Imp-L2 promotes insulin signaling in distinct neurons of the Drosophila brain" @default.
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- W2326860462 doi "https://doi.org/10.1242/dev.100065" @default.
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